Galectin-8 Expression in Laryngeal Squamous Cell Carcinoma

동근우; 김준; 박준희; 최지윤; 조성일; 임성철

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자료유형: 학술저널

저자정보: 동근우 김준 박준희 최지윤 조성일 임성철

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제2권 제1호

발행연도: 2009.1

수록면: 13 - 19 (7page)

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Objectives. Despite the ongoing development of treatment protocols for laryngeal squamous cell carcinoma (LSCC), the patients suffering with this malady have shown only a modestly improved outcome. This poor outcome has been attributed to the lack of therapy that’s individualized to the tumor’s biological properties. Various studies have showed that galectin-8 is widely expressed in tumor tissues as well as in normal tissues, and the level of the galectin-8 expression may correlate with the malignancy of human squamous cell carcinoma. The purpose of this study is to evaluate the expression of galectin-8 and to investigate its correlations with the primary stage, the nodal involvement, the clinical stage and the histologic grade of squamous cell carcinoma of the larynx. Methods. The paraffin-embedded tissue specimens from 77 patients who were diagnosed as LSCC between 1993 and 2007 were immunohistochemically stained for galectin-8. Results. Immunohistochemical analysis showed that a strong positive expression of galectin-8 was correlated with the T-stages, the nodal stages and the clinical stages. However, the histopathologic grades were not correlated with the galectin-8 expression in LSCC. Conclusion. The expression of galectin-8 protein can be used as a prognostic factor for patients with LSCC.

#Galectin-8 #Immunohistochemistry #Larynx #Squamous cell carcinoma

참고문헌 (25)

참고문헌 신청

Barondes SH / 1994 / Cummings RD, Drickamer K, Feizi T, et al. Galectins: a family of animal beta-galactoside-binding lectins / Cell 76 (4) : 597 ~ 598

Bidon N / 2001 / Galectin-8: a complex sub-family of galectins (Review) / Int J Mol Med. 8 (3) : 245 ~ 250

Bidon-Wagner N / 2004 / Human galectin-8 isoforms and cancer / Glycoconj J. 19 (7) : 557 ~ 563

Danguy A / 2001 / Immunohistochemical profile of galectin-8 expression in benign and malignant tumors of epithelial, mesenchymatous and adipous origins, and of the nervous s

Danguy A / 2002 / Galectins and cancer / Biochim Biophys Acta 1572 (2) : 285 ~ 293

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