지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.7
- 수록면
- 29 - 36 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: There are few molecular markers useful in practice for predicting prognosis of papillary thyroid carcinoma (PTC) despite numerous basic researches. The objective of this study was to evaluate the prognostic values of several candidate markers of PTC (p53, Ki-67 and galectin-3) using immunohistochemistry (IHC), one of the most practical methods.
Methods: IHC for p53, Ki-67 and galectin-3 were performed on formalin-fixed paraffin-embedded tissues of 160 PTC specimens using monoclonal antibodies. The associations of the expressions of these markers with multiple clinicopathologic prognostic factors were assessed.
Results: The overexpresion rates of p53, Ki-67 and galectin-3 were 48.8%, 64.3% and 97.8%, respectively. Overexpression of p53 protein was positively associated with extrathyroidal extension (P＜0.001). In addition, p53 immunoreactivity was more prevalent among Ki-67 overexpressed specimens (P＜0.001). Ki-67 immunoreactivity was positively correlated with tumor size (P＜0.05), which became more distinct when accompanied with p53 overexpression (P＜0.01). In contrast, no relationship between galectin-3 immunoreactivity and clinical prognostic factors was found.
Conclusion: Our results suggest that overexpression of p53 protein and Ki-67 in papillary thyroid carcinoma is associated with tumor progression and that IHC for these proteins could be useful for predicting prognosis of patients with PTC.
Methods: IHC for p53, Ki-67 and galectin-3 were performed on formalin-fixed paraffin-embedded tissues of 160 PTC specimens using monoclonal antibodies. The associations of the expressions of these markers with multiple clinicopathologic prognostic factors were assessed.
Results: The overexpresion rates of p53, Ki-67 and galectin-3 were 48.8%, 64.3% and 97.8%, respectively. Overexpression of p53 protein was positively associated with extrathyroidal extension (P＜0.001). In addition, p53 immunoreactivity was more prevalent among Ki-67 overexpressed specimens (P＜0.001). Ki-67 immunoreactivity was positively correlated with tumor size (P＜0.05), which became more distinct when accompanied with p53 overexpression (P＜0.01). In contrast, no relationship between galectin-3 immunoreactivity and clinical prognostic factors was found.
Conclusion: Our results suggest that overexpression of p53 protein and Ki-67 in papillary thyroid carcinoma is associated with tumor progression and that IHC for these proteins could be useful for predicting prognosis of patients with PTC.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [보고서] - Ministry for Health, Welfare and Family Affairs / 2008 / Annual Report of cancer incidence (2005) and survival (1993-2005) in Korea
2. [학술지(정기간행물)] - Ain KB / 1995 / Papillary thyroid carcinoma. Etiology, assessment, and therapy / Endocrinol Metab Clin North Am 24 : 711 ~ 760
3. [학술지(정기간행물)] - Mazzaferri EL / 1994 / Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer / Am J Med 97 : 418 ~ 428
4. [학술지(정기간행물)] - Levine AJ / 1991 / The p53 tumour suppressor gene / Nature 351 : 453 ~ 456
5. [학술지(정기간행물)] - Farid NR / 2001 / P53 mutations in thyroid carcinoma: tidings from an old foe / J Endocrinol Invest 24 : 536 ~ 545
2. [학술지(정기간행물)] - Ain KB / 1995 / Papillary thyroid carcinoma. Etiology, assessment, and therapy / Endocrinol Metab Clin North Am 24 : 711 ~ 760
3. [학술지(정기간행물)] - Mazzaferri EL / 1994 / Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer / Am J Med 97 : 418 ~ 428
4. [학술지(정기간행물)] - Levine AJ / 1991 / The p53 tumour suppressor gene / Nature 351 : 453 ~ 456
5. [학술지(정기간행물)] - Farid NR / 2001 / P53 mutations in thyroid carcinoma: tidings from an old foe / J Endocrinol Invest 24 : 536 ~ 545
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
양성 및 악성 유방 종양에서 Galectin 3 단백발현에 관한 연구
Annals of Surgical Treatment and Research
2007 .12
-
갑상선 종양에서 Galectin-3 발현의 임상적 의의
대한이비인후-두경부외과학회지
2006 .01
-
갑상선 결절의 Ki67과 p27 발현도에 대한 분석
대한 두경부 종양 학술지
1999 .01
-
갑상선 종양에서의 Galectin-3 발현에 관한 분석
대한외과학회 학술대회 초록집
2002 .10
-
Galectin-8 Expression in Laryngeal Squamous Cell Carcinoma
Clinical and Experimental Otorhinolaryngology
2009 .01
-
악성 상피성 난소종양에서 Ki-67의 발현에 관한 연구
Obstetrics & Gynecology Science
2008 .01
-
The Expression of Galectin-3, a Beta-Galactoside Binding Protein, in Dendritic Cells
Immune Network
2005 .06
-
갑상선 종양에서 신생혈관 생성 및 Ki67 발현
대한이비인후-두경부외과학회지
2004 .01
-
결장 및 직장암에서 Ki- 67 Index의 임상적인 의의
Annals of Surgical Treatment and Research
2007 .04
-
三陰三陽經脈의 發生과 機能
대한한의학원전학회지
1999 .01
-
Galectin-9 Acts as a Prognostic Factor with Antimetastatic Potential in Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Clinicopathologic and Diagnostic Significance of p53 Protein Expression in Papillary Thyroid Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Ki67 Index in Breast Cancer: Correlation with Other Prognostic Markers and Potential in Pakistani Patients
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Expression of Ki67 in Papillary Thyroid Microcarcinoma and its Clinical Significance
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Immunohistochemical and Molecular Markers Associated with Differentiated Thyroid Carcinoma
International Journal of Thyroidology
2015 .01
-
수술 전 세침흡입 세포검사에서 악성감별이 어려운 갑상선 결절에 대한 Galectin-3 면역조직화학 염색의 진단적 유용성
Annals of Surgical Treatment and Research
2004 .06
-
Galectin-1, -3, -7 Expressions in Congenital and Acquired Pediatric Cholesteatomas Compared to External Auditory Canal Skin
Clinical and Experimental Otorhinolaryngology
2012 .01
-
Correlations between HER2 Expression and Other Prognostic Factors in Breast Cancer: Inverse Relations with the Ki-67 Index and P53 Status
Asian Pacific journal of cancer prevention : APJCP
2016 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0