부비동 내시경 수술 후 GUARDIX-SL?의 유착방지 효과

이주환; 윤현철; 박태준; 김정홍; 김경수; 윤주헌; 송기재

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자료유형: 학술저널

저자정보: 이주환 윤현철 박태준 김정홍 김경수 윤주헌 송기재

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제12호

발행연도: 2005.1

수록면: 1,478 - 1,483 (6page)

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연구배경

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연구결과

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Background and Objectives：Adhesion after sinus surgery represents a potential source of surgical failure. GUARDIX-SL?? which is composed of sodium hyaluronate and sodium carboxymethyl cellulose, is an effective agent that can be used as a surgical adjuvant to decrease adhesion in the abdominal surgery. Therefore, we evaluated the clinical efficacy and safety of the GUARDIXSL ?? for the prevention of adhesion after endoscopic sinus surgery. Subjects and Method：This study was randomized and double-blinded. At the completion of endoscopic sinus surgery, 6 mL GUARDIX-SL was applied on Merocel and repeatedly applied on the middle meatus after removal of Merocel (n=22). As a control group, normal saline was applied instead of GUARDIX- SL (n=22). Endoscopic examination was performed at 3 days, 1 week, 2 weeks, and 4 weeks, postoperatively. Adhesion formation was graded as G0-G4, and CT scoring was also performed. Results：The rate of adhesion formation was the highest at 2 weeks after operation and was significantly lower in the GUARDIX-SL?? treated group than in the control throughout the period of observation. The cases were divided into 3 groups according to the CT scores at 2 weeks after operation：The groups with the GUARDIX-SL?? treatment also showed lower adhesion formation than the control. The safety profile of the patients was normal at 4 weeks postoperatively. Conclusion：The results suggest that GUARDIX-SL?? may be an efficacious and safe material in decreasing the incidence of adhesion after sinus surgery.

#부비동·유착·내시경 수술·유착방지제. #Paranasal sinuses·Adhesion·Endoscope·Prevention.

참고문헌 (20)

참고문헌 신청

Bar A / 1995 / Timonen M. Metabolic disposition in rats ofregular and enzymatically depolymerized sodium carboxymethylcellulose.Food Chem Toxicol 1995 : 901 ~ 7

Baumann A / .2003 / Caversaccio M. Hemostasis in endoscopic sinus surgeryusing a specific gelatin-thrombin based agent : 244 ~ 9

Catalano PJ / 2003 / Roffman EJ. Evaluation of middle meatal stenting afterminimally invasive sinus techniques : 875 ~ 81

Chandra RK / 2004 / Kern RC. Advantages and disadvantages of topicalpacking in endoscopic sinus surgery. Curr Opin Otolaryngol HeadNeck Surg 2004 : 21 ~ 6

Chung JH / 2002 / Metson RB. Mitomycin C for theprevention of adhesion formation after endoscopic sinus surgery : 468 ~ 74

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