구강 및 구인두 편평세포암종에서 Hepatocyte Growth Factor와c-met 유전자 발현의 의의

김진환; 오소정; 노영수; 안회영; 신형식; 조성진

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자료유형: 학술저널

저자정보: 김진환 오소정 노영수 안회영 신형식 조성진

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제50권 제8호

발행연도: 2007.1

수록면: 684 - 689 (6page)

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Background and Objectives：The hepatocyte growth factor (HGF)/c-Met signal pathway may play various roles in carcino-genesis of several organs. However, studies about this pathway in head and neck cancers, especially oral cavity and oropharyn-geal squamous cel carcinoma (SCC), are very rare. Our objectives are to evaluate the relationship between the mRNA and protein expression of HGF and c-met genes in oral cavity and oropharyngeal carcinomas. Subjects and Method：examined the mRNA expresion of HGF and c-Met by means of the immunohistochemistry (IHC) method and reverse tran-scription polymerase chain reaction (RT-PCR) in 40 cases of surgically resected oral cavity and oropharyngeal SCC and 10 cases of low grade dysplasia. Results：Using RT-PCR , HGF mRNA amplification was detected in 67.5% and 10% of carcinoma and dysplasia. c-Met mRNA over-expresion was detected in 57.5% and 20% of carcinoma and dysplasia. Using IHC, HGF and Conclusion：These results suggest that HGF/c-Met signal pathway may be associated with the development of oral cavity and oropharyngeal SCC. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :684-9)

#구강·구인두·편평세포암종·간세포 성장 인자·원발암유전자 c-Met 단백. #Oral cavity· Oropharynx· Squamous cell carcinoma· Hepatocyte growth factor· Proto-oncogene c-Met proteins.

참고문헌 (13)

참고문헌 신청

/ / Ferlito A. Histological classification of larynx and hypopharynx cancersand their clinical implications-Pathologic aspect of 2052 malignantneoplasm diagnosed at the ORL d

/ / Hart IR. The biology of cancer invasion andmetastasis. Adv Cancer Res 1978 : 149 ~ 250

/ / Kramer RH. Hepatocytegrowth factor/scatter factor induces tyrosine phosphorylation of focaladhesion kinase : 31807 ~ 13

/ / Spang-Thomsen M. Expression of the proto-oncogenes c-met and c-kit and their ligands : 37 ~ 46

/ / Tahara E. Aberrantexpression of c-met mRNA in human gastric carcinomas. Int J Cancer1993 : 72 ~ 5

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