겐타마이신으로 유발된 기니픽 전정유모세포 손상과 재생

이정구; 정재윤; 최원일; 전상준; 장선오

추천

검색

자료유형: 학술저널

저자정보: 이정구 정재윤 최원일 전상준 장선오

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제3호

발행연도: 2005.1

수록면: 302 - 309 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background and Objectives：The recovery of the vestibular sensory epithelia of guinea pigs after gentamicin (GM) induced hair cell injury was asessed both quantitatively and qualitatively with a functional study of the vestibular system using animal rotatory chair. Materials and Method：Evaluations were made via calculating the number of utricle cells bearing hair bundles (SEM). The number of ampullar hair cells and supporting cells were calculated by toluidine blue staining. Animal rotatory chair test was performed for the evaluation of functional recovery of vestibular system after gentamicin damage in guinea pigs. Results：The initial loss of hair cells in utricle and ampulla were followed by the recovery of hair cell number. The quantitative analyses indicated that the lost hair cells were replaced or regenerated after the end of GM administration, or at 3 months. SEM revealed the morphological recovery of the damaged hair cels and new hair cell regenera-a-tion, and the gain increased over 3 months. The value of bias of the vertical axis rotation also decreased immediatly after the GM application, and the decreased value of bias were partialy recovered. Conclusion：We find guinea pig vestibular hair cell regeneration after gentamicin damage with morphologic and functional study.

#전정유모세포·재생·겐타마이신. #Vestibular hair cel· Regeneration· Gentamicin.

참고문헌 (20)

참고문헌 신청

/ 1987 / Light microscopic evidence ofhair cell regeneration after gentamicin toxicity in chick cochlea 113 : 1058 ~ 62

/ 1992 / Hair cell regeneration in the avian vestibularepithelium 115 : 2 ~ 6

/ 1992 / Hair cell regeneration inthe adult budgerigar after kanamycin ototoxicity 59 : 46 ~ 58

/ 1993 / Hair cell regeneration in the bullfrogvestibular otolith organs following aminoglycoside toxicity 65 : 164 ~ 74

/ 1993 / Regenerativeproliferation in inner ear sensory epithelia from adultguinea pigs and humans 259 : 1619 ~ 22

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!