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Background and Objectives:The idiopathic sudden sensorineural hearing loss (ISSHL) is a disease occuring instantly or hearing recovery in ISSHL, but the effects of acyclovir are stil uncertain. The purpose of this study is to evaluate the therapeutic efficacy of antiviral drug acyclovir (Zoylex) in ISSHL. Materials and Methods:One hundred thirty four ears were divided into a study (41 ears, using acyclovir and steroid) and a control (93 ears, using steroid only) groups. Prognostic rs of comparison betwen two groups. Results:The overall recovery rate of the study group (53.7%) was better than that of the control group (46.2%), but it was not statistically significant (p>0.05). The recovery rate of the study group was better than that of the control group on some prognostic factors, especially the period betwen the symptom attack and the be-ginning of treatment;however, there were no statistically significant diferences either (p 0.05). Conclusion:Therefore, no beneficial efects from combining acyclovir with prednisolone could be established in ISSHL. (Korean J Otolaryngol 2002;45:225-30)

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