지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 139 - 145 (7page)
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초록· 키워드
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Background: The plasma B-type natriuretic peptide (BNP) level is a useful prognostic marker in heart failure and valvular heart disease. In patients with isolated severe tricuspid regurgitation (TR), little is known about the determinants of plasma BNP levels and the correlation with future outcome. The purpose of this study was to identify the determinants of plasma BNP levels in patients with isolated severe TR and the value of the BNP level in predicting postoperative outcomes after corrective surgery.
Methods:We prospectively enrolled 39 patients with isolated, severe TR undergoing corrective surgery. A plasma BNP assay and cardiac magnetic resonance (CMR) imaging were performed before surgery. The combined end-point was the occurrence of cardiac death or readmission due to heart failure.
Results: Linear regression analysis showed that the left ventricular ejection fraction and right ventricular end systolic volume were the most important determinants of the BNP levels (p = 0.002, R2 = 0.315). Based on the receiver operating characteristics (ROC) curve, we were able to derive an optimal cutoff value (200 pg/mL) to predict postoperative cardiac death with a sensitivity of 80% and a specificity of 85%. The one-year survival rate was 96% in patients with a BNP < 200 pg/mL and 53% in patients with a BNP ≥ 200 pg/dL (p = 0.001).
Conclusion: An elevation in the BNP level is determined by the functional status of the right and left ventricles in patients with isolated, severe TR. An elevated BNP predicts adverse events after corrective surgery. Therefore, the BNP level should be included in the clinical evaluation and risk stratification of patients with isolated TR.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Czer LS / 1989 / Tricuspid valve repair. Operative and follow-up evaluation by Doppler color flow mapping / J Thorac Cardiovasc Surg 98 : 101 ~ 110
Detaint D / 2005 / B-type natriuretic peptide in organic mitral regurgitation: determinants and impact on outcome / Circulation 111 : 2391 ~ 2397
Grothues F / 2004 / Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance / Am Heart J 147 : 218 ~ 223
Groves PH / 1991 / Reduced exercise capacity in patients with tricuspid regurgitation after successful mitral valve replacement for rheumatic mitral valve disease / Br Heart
Ikeda K / 1997 / Synthesis of N-acetylglucosaminyl- and N-acetylgalactosaminylceramides as cerebroside analogs and their anti-human immunodeficiency virus type 1 activities
Detaint D / 2005 / B-type natriuretic peptide in organic mitral regurgitation: determinants and impact on outcome / Circulation 111 : 2391 ~ 2397
Grothues F / 2004 / Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic resonance / Am Heart J 147 : 218 ~ 223
Groves PH / 1991 / Reduced exercise capacity in patients with tricuspid regurgitation after successful mitral valve replacement for rheumatic mitral valve disease / Br Heart
Ikeda K / 1997 / Synthesis of N-acetylglucosaminyl- and N-acetylgalactosaminylceramides as cerebroside analogs and their anti-human immunodeficiency virus type 1 activities
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