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학술저널
저자정보
Bang, Sun-Hee (Division of Pediatric Cardiology, Department of Pediatrics, University of Ulsan College of Medicine) Yu, Jeong-Jin (Division of Pediatric Cardiology, Department of Pediatrics, University of Ulsan College of Medicine) Han, Myung-Ki (Division of Pediatric Cardiology, Department of Pediatrics, University of Ulsan College of Medicine) Ko, Hong-Ki (Division of Pediatric Cardiology, Department of Pediatrics, University of Ulsan College of Medicine) Chun, Sa-Il (Department Laboratory Medicine, University of Ulsan College of Medicine) Choi, Hyung-Soon (Department of Pediatrics, Kosin University College of Medicine) Kim, Young-Hwue (Division of Pediatric Cardiology, Department of Pediatrics, University of Ulsan College of Medicine) Ko, Jae-Kon (Division of Pediatric Cardiology, Department of Pediatrics, University of Ulsan College of Medicine) Park, In-Sook (Division of Pediatric Cardiology, Department of Pediatrics, University of Ulsan College of Medicine)
저널정보
대한소아청소년과학회 Clinical and Experimental Pediatrics Korean journal of pediatrics 제54권 제8호
발행연도
2011.1
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340 - 344 (5page)

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Purpose: Brain natriuretic peptide (BNP) has been considered a biochemical marker for myocarditis in Kawasaki disease. We performed this study to determine its quantitative significance. Methods: We attempted to correlate log-transformed BNP concentrations (log-BNP) and clinical, laboratory, and echocardiographic variables in 81 children with Kawasaki disease. Stepwise multiple linear regression analysis was used to determine the variables independently associated with log-BNP concentration. Results: Serum C-reactive protein level (P<0.0001), serum alanine aminotransferase concentration (P =0.0032), white blood cell count (P=0.0030), and left ventricular mass index (P=0.0024) were positively related with log-BNP, and hemoglobin level (P<0.0001), serum albumin level (P<0.0001), $Na^+$ concentrations (P<0.0001), left ventricular fractional shortening (P=0.0080), and peak early diastolic tissue velocity of the left ventricular basal lateral segment (P=0.0045) were negatively related to the log-BNP concentration. Multiple regression analysis showed that serum albumin concentration ($R_2$=0.31, P=0.0098) and left ventricular mass index ($R_2$=0.09, P=0.0004) were significantly associated with the log-BNP concentration. Conclusion: Elevated BNP levels during the acute phase of Kawasaki disease may be attributable to cardiac dysfunction associated with the increase in left ventricular mass, and log-BNP concentration may be a quantitative biochemical marker of myocarditis in Kawasaki disease.

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