지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 60 - 69 (10page)
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초록· 키워드
오류제보하기
Background: Granulocyte stimulating factor (G-CSF) and bone marrow mononuclear cells (BM-MNC) were reported to improve cardiac function after myocardial infarction (MI). This study was to examine their combined beneficial effects and mechanisms of actions in reperfused MI, which have not been verified yet.
Methods: Fifteen pigs were divided into 3 groups after a 1-hour balloon occlusion and reperfusion of the left anterior descending coronary artery. G1 (n=5) was a control, G2 (n=5) was a G-CSF injected group (10 ug/kg/day, from day1 to day7 after MI), and G3 (n=5) was an autologous intracoronary BM-MNC infused group after G-CSF treatment.
Results: Modified wall motion indices by echocardiography were similar among 3 groups at 24 hours after MI. However, they improved significantly in G2 and G3 at 35days after MI (p＜0.05). The percentage of infarct area/left
ventricular myocardial area measured from a triphenyltetrazolium chloride (TTC) stain was lower in G3 than in G1 or G2 (p=0.026). The number of vWF-positive vessels and the expressions of vWF and VE cardherin by RT-PCR were higher in G3 and G2 than in G1 (p＜0.05). The number of TUNEL-positive cells and bcl2/bax ratio were not significantly different among 3 groups.
Conclusion: This study suggests that intracoronary BM-MNC infusion with G-CSF treatment in reperfused MI reduced infarct size, improved left ventricular function and prevented ventricular remodeling.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Adachi Y / 2004 / G-CSF treatment increases side population cell infiltration after myocardial infarction in mice / J Mol Cell Cardiol 36 : 707 ~ 710
Balsam LB / 2004 / Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium / Nature 428 : 668 ~ 673
Braunwald E / 1994 / Late establishment of patency of the infarctrelated artery / Saunders
Harada M / 2005 / G-CSF prevents cardiac remodelingafter myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes / Nat Med 11 : 305 ~ 311
Iwanaga K / 2004 / Effe
Balsam LB / 2004 / Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium / Nature 428 : 668 ~ 673
Braunwald E / 1994 / Late establishment of patency of the infarctrelated artery / Saunders
Harada M / 2005 / G-CSF prevents cardiac remodelingafter myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes / Nat Med 11 : 305 ~ 311
Iwanaga K / 2004 / Effe
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