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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 7 (7page)
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Recent in vitro studies have demonstrated that extract of soft coral Dendronephthya gigantea (SCDE) had strong anti-inflammatory activities. However, the direct effects of SCDE on anti-inflammatory activities in vivo model remained to be determined. Therefore, the present study was designed to assess in vivo anti-inflammatory effect of SCDE using lipopolysaccharide (LPS)-stimulated zebrafish model. We also investigated whether SCDE has toxic effects in zebrafish model. The survival, heart beat rate, and developmental abnormalities were no significant change in the zebrafish embryos exposed to at a concentration below 100 μg/ml of SCDE. However, lethal toxicity was caused after exposure to 200 and 400 μg/ml of SCDE. Treating zebrafish model with LPS treatment significantly increased the reactive oxygen species (ROS) and nitric oxide (NO) generation. However, SCDE inhibited this LPS-stimulated ROS and NO generation in a dose-dependent manner. These results show that SCDE alleviated inflammation by inhibiting the ROS and NO generation induced by LPS treatment. In addition, SCDE has a protective effect against the cell damage induced by LPS exposure in zebrafish embryos. This outcome could explain the profound anti-inflammatory effect of SCDE both in vitro as well as in vivo, suggesting that the SCDE might be a strong anti-inflammatory agent.
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참고문헌 (24)
참고문헌 신청
Ali S / 2011 / Zebrafish embryos and larvae : a new generation of disease models and drug screens / Birth Defects Res C Embryo Today 93 : 115 ~ 133
Blunt JW / 2012 / Marine natural products / Nat Prod Rep 29 : 144 ~ 222
Chao CH / 2008 / Anti-inflammatory steroids from the octocoral Dendronephthya griffin / Tetrahedron 64 : 3554 ~ 3560
Cho IY / 2014 / A study on the biodiversity of benthic invertebrates in the waters of Seogwipo, Jeju Island, Korea / J Asia Pac Biodivers 7 : e11 ~ e18
De LE / 2014 / ZebraBeat: a flexible platform for the analysis of the cardiac rate in zebrafish embryos / Sci Rep 4 : 649 ~ 652
Blunt JW / 2012 / Marine natural products / Nat Prod Rep 29 : 144 ~ 222
Chao CH / 2008 / Anti-inflammatory steroids from the octocoral Dendronephthya griffin / Tetrahedron 64 : 3554 ~ 3560
Cho IY / 2014 / A study on the biodiversity of benthic invertebrates in the waters of Seogwipo, Jeju Island, Korea / J Asia Pac Biodivers 7 : e11 ~ e18
De LE / 2014 / ZebraBeat: a flexible platform for the analysis of the cardiac rate in zebrafish embryos / Sci Rep 4 : 649 ~ 652
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