지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 797 - 807 (11page)
이용수
초록· 키워드
오류제보하기
Objectives : The purpose of this study was to investigate whether Mahwangyunpye-tang(MYT) significantly affects mucin secretion from airway epithelial cells.Methods : Confluent hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of MYT to assess the effect of the agent on 3H-mucin secretion. Total elution profiles of control spent media and treatment sample through Sepharose CL-4B column were analyzed. Effect of MYT on contractility of isolated tracheal smooth muscle was investigated; also investigated was effect of the agent on MUC5AC gene expression in cultured NCI-H292 cells. Possible cytotoxicities of the agent were assessed both by measuring lactate dehydrogenase (LDH) release from HTSE cells and examining the rate of survival and proliferation of NCI-H292 cells.Results : MYT significantly increased mucin secretion from cultured HTSE cells, without significant cytotoxicity. MYT chiefly affected the 'mucin' secretion. MYT inhibited Acetylcholine-induced contraction of isolated tracheal smooth muscle. MYT did not significantly affect the expression levels of MUC 5AC gene in cultured NCI-H292 cells.Conclusions : Based on the above results, it is suggested that MYT increased mucin secretion from cultured HTSE cells without significant cytotoxicity and inhibited contraction of isolated tracheal smooth muscle.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ 1998 / 경산대학교부속한방병원 원내처방집 : 53 ~
Freshney IR / wiley-liss;1994 / Culture of animal cells
Kim KC / 1985;21 / Possible requirement of collagen gel substratum for production of mucinlike glycoproteins by primary rabbit tracheal epithelial cells in culture : 617 ~ 2
Kim KC / 1985;260 / Biochemical characterization of mucous glycoproteins synthesized and secreted by hamster tracheal epithelial cells in primary culture : 4021 ~ 7
Kim KC / 1989;43 / Use of primary cell culture to study regulation of airway surface epithelial mucus secretion : 231 ~ 9
Freshney IR / wiley-liss;1994 / Culture of animal cells
Kim KC / 1985;21 / Possible requirement of collagen gel substratum for production of mucinlike glycoproteins by primary rabbit tracheal epithelial cells in culture : 617 ~ 2
Kim KC / 1985;260 / Biochemical characterization of mucous glycoproteins synthesized and secreted by hamster tracheal epithelial cells in primary culture : 4021 ~ 7
Kim KC / 1989;43 / Use of primary cell culture to study regulation of airway surface epithelial mucus secretion : 231 ~ 9
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
射干麻黃湯 및 <石室秘錄＞逆醫法方이 호흡기 점액의 분비에 미치는 영향
대한한방내과학회지
2006 .01
-
Mucin 분비에 미치는 大靑龍湯 및 <石室秘？＞急治法方에 대한 연구
대한한방내과학회지
2006 .01
-
Effect of Ambroxol on Secretion, Production and Gene Expression of Mucin from Cultured Airway Epithelial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2011 .01
-
仙方敗毒湯이 호흡기 뮤신 분비 및 기관 평활근 긴장도에 미치는 영향
대한한방소아과학회지
2007 .01
-
The Study on Mucin Release by Airway Goblet Cells in Primary Culture
한국응용약물학회 춘계학술발표논문집
1995 .01
-
淸燥救肺湯과 理陰煎이 호흡기 점액분비에 미치는 영향
대한한방내과학회지
2008 .01
-
Effect of Berberine on MUC5AC Mucin Gene Expression and Mucin Production from Human Airway Epithelial Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2011 .01
-
c-Jun N-terminal Kinase 1 and Myt1 as Potential Targets for UVA-induced Skin Cancer
환경독성보건학회 심포지엄 및 학술대회
2009 .11
-
히스티딘 중합체가 일차배양 기도 상피세포에서의 뮤신 유리에 미치는 영향
약학회지
2010 .01
-
Effect of Platycodin D on Airway MUC5AC Mucin Production and Gene Expression Induced by Growth Factor and Proinflammatory Factor
Biomolecules & Therapeutics(구 응용약물학회지)
2010 .01
-
사람 정상 코점막 상피세포에서 겔 형성 점소(Gel-Forming Mucin)분비에 대한 Prostaglandin E₂의 효과
대한이비인후-두경부외과학회지
2006 .01
-
호흡기 배상세포에서 폴리양이은성 펩티드에 의해 야기되는 뮤신유리 억제 현상의 특이성 규명 Specificity in the Inhibition of Mucin Release from Airway Goblet Cells by Polycationic Peptides
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2001 .01
-
중합도 50mer 이하의 염기성 아미노산 중합체들이 일차배양 햄스터 기관표면 상피세포에서의 생리적 뮤신유리 및 분비자극 상태에서의 뮤신유리에 미치는 영향
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
2002 .01
-
가미육군자탕(加味六君子湯)이 호흡기 뮤신분비 및 뮤신 유전자 발현에 미치는 영향
동의생리병리학회지
2007 .01
-
健肺湯이 호흡기 뮤신의 생성 및 유전자 발현에 미치는 영향
대한한방내과학회지
2009 .01
-
호흡기 상피세포에서 Vasoactive Intestinal Peptide에 의한 MUC2/5AC 생성
대한이비인후-두경부외과학회지
2004 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0