지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 307 - 312 (6page)
이용수
초록· 키워드
오류제보하기
Background and Objectives：Recently, Prostaglandin E2 (PGE2) was found to induce MUC5AC production via an agonist of E-prostanoid (EP2/EP4), but not EP1/EP3, in normal human airway epithelium. However, the receptor that mediates MUC5AC has not been determined. This study was aimed to investigate the MUC5AC mucin gene and mucin secretion by PGE2 and its receptors in cultured normal human nasal epithelial cells. Materials and Method：After treatment with PGE2 and/or PGE2 antagonist, gel-forming mucin mRNA expression was determined by reverse transcription-polymerase chain reaction. Total mucin and MUC5AC mucin levels were measured using an immuno-dot blotting assay. Results：PGE2 increased the MUC5AC gene expressions and MUC5AC mucin, but not the expressions of other gel-forming mucin genes. An EP2 receptor antagonist (AH6809) did not suppress the PGE2-induced MUC5AC gene expression or MUC5AC mucin. However, an EP4 receptor antagonist (AH23848) significantly suppressed the level of PGE2-induced MUC5AC gene expression and MUC5AC mucin. Conclusion：These findings indicate that PGE2 induces MUC5AC gene expression and mucin secretion via EP4 receptor in cultured normal human nasal epithelialcells. (Korean J Otolaryngol 2006;49:307-12)
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
/ 1996 / Prostaglandin E2 receptors of the EP2 and EP4subtypes regulate activation and differentiation of mouse B lymphocytesto IgE-secreting cells 93 : 10973 ~ 10983
/ 1997 / Regulation of thesecretory phenotype of human airway epithelium by retinoic acid, triiodothyronine,and extracellular matrix 16 : 724 ~ 731
/ 1998 / Changes in expression of 15-lipoxygenaseand prostaglandin-H synthase during differentiation of humantracheobrochial epithelial cells 18 : 662 ~ 669
/ 1999 / EP4 receptor mediation of prostaglandinE2-stimulated mucus secretion by rabbit gastric epithelialcells 58 : 1997 ~ 2002
/ 1999 / Effects of TNF-αand IL-1β on mucin IL-6 and IL-8 in passage-2 normal humannasal epithelial cells 119 : 905 ~ 910
/ 1997 / Regulation of thesecretory phenotype of human airway epithelium by retinoic acid, triiodothyronine,and extracellular matrix 16 : 724 ~ 731
/ 1998 / Changes in expression of 15-lipoxygenaseand prostaglandin-H synthase during differentiation of humantracheobrochial epithelial cells 18 : 662 ~ 669
/ 1999 / EP4 receptor mediation of prostaglandinE2-stimulated mucus secretion by rabbit gastric epithelialcells 58 : 1997 ~ 2002
/ 1999 / Effects of TNF-αand IL-1β on mucin IL-6 and IL-8 in passage-2 normal humannasal epithelial cells 119 : 905 ~ 910
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