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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 331 - 345 (15page)
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초록· 키워드
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Objectives : This study was designed to investigate the effects of Saenggantanggami-bang (SG) on nonalcoholic fatty liver disease.
Methods : HepG2 cells were used in an in vitro model. HepG2 cells were divided into three groups. The Normal group was incubated with no fatty acid. The Control group was incubated with 1mM palmitic acid to introduce fat overloading. The PA-SG group was incubated with 1mM palmitic acid and various concentrations of Saenggantanggami-bang (SG). Cell viability and cytotoxicity were analyzed by MTT assay and LDH assay. Intracellular triglyceride (TG) levels, reactive oxygen species (ROS) levels, ATP amount, and GST activity were measured. Cell death pattern and protective effect of SG on cell death were studied by DNA fragmentation and caspase-3 intensity (western blot).
Results : Compared with the Control group, cell viability of the PA-SG group significantly increased (P<0.01), cytotoxicity of the PA-SG group decreased (P<0.01), and intracellular TG levels and ROS levels of the PA-SG group decreased (P<0.05). In DNA fragmentation assay, necrotic pattern was observed and DNA fragment decreased in the PA-SG group. In western blot, apoptotic pattern was observed, caspase-3 intensity of the PA-SG group was reduced significantly, but there were no significant differences in intracellular ATP amount and GST activity between the control group and the PA-SG group.
Conclusion : The results suggest that Saenggantanggami-bang can be a potential candidate for the clinical treatment of nonalcoholic fatty liver disease.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
?其? / 2007 / 脂炎消煎?治療非酒精性脂肪肝 63例的臨床觀察 / CJ GMTCM 22 (2) : 34 ~ 35
?和平 / 2007 / 降脂益肝??治療非酒精性脂肪肝炎的實驗硏究 / Drug evaluation 4 (2) : 114 ~ 116
Adams LA / 2005 / Recent concepts in nonalcoholic fatty liver disease / Diabet Med 22 : 1129 ~ 1133
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med. 346 : 1221 ~ 1231
Bakon BR / 1994 / Nonalcoholic steatohepatitis: an expanded clinical entity / Gastroenterology 107 : 1103 ~ 1109
?和平 / 2007 / 降脂益肝??治療非酒精性脂肪肝炎的實驗硏究 / Drug evaluation 4 (2) : 114 ~ 116
Adams LA / 2005 / Recent concepts in nonalcoholic fatty liver disease / Diabet Med 22 : 1129 ~ 1133
Angulo P / 2002 / Nonalcoholic fatty liver disease / N Engl J Med. 346 : 1221 ~ 1231
Bakon BR / 1994 / Nonalcoholic steatohepatitis: an expanded clinical entity / Gastroenterology 107 : 1103 ~ 1109
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