지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.7
- 수록면
- 248 - 255 (8page)
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초록· 키워드
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Potential antioxidant effect of processed ginseng(sun ginseng, SG) on oxidative stress generated by tert-butyl hydroperoxide (t-BHP) was investigated in HepG2 cells. 3-(4,5-Dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide assay and lactate dehydrogenase (LDH) leakage test demonstrated that SG dose-dependently prevents a loss of cell viability against t-BHP-induced oxidative stress. Also, SG treatment dose-dependently relieved the increment of activities of hepatic enzymes, such as aspartate aminotrasferase and alanine aminotransferase, and lipid peroxidation mediated by t-BHP treatment in HepG2 cells. SG increased the gene expression of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. However, high dose of SG treatment caused decrease in mRNA level of glutathione peroxidase as compared to low dosage of SG-treated cells. The gene expression of glutathione reductase was found to be slightly increased by SG treatment. In addition, SG extract attributed its hepaprotective effect by inducing the mRNA level of bcl-2 and bcl-xL but reducing that of bax. But, the gene expression of bad showed no significant change in SG-treated HepG2 cells. These findings suggest that SG has hepatoprotective effect by showing reduction of LDH release, activities of hepatic enzymes and lipid peroxidation and regulating the gene expression of antioxidant enzymes and apoptosis-related molecules against oxdative stress caused by t-BHP in HepG2 cells.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (30)
참고문헌 신청
1. [학술지(정기간행물)] - Vitaglione P / 2004 / Dietary antioxidant compounds and liver health / Crit Rev Food Sci Nutr 44 : 575 ~ 586
2. [학술지(정기간행물)] - Adachi M / 2002 / Role of mitochondria in alcoholic liver injury / Free Radic Biol Med 32 : 487 ~ 491
3. [학술지(정기간행물)] - Hyun-Jeong Kim / 2010 / Effects of Fermented Red Ginseng Extracts on Hyperglycemia in Streptozotocin-induced Diabetic Rats / Journal of Ginseng Research 34 (2) : 104 ~ 112
4. [학술지(정기간행물)] - Myung-Haeng Hur / 2010 / Ginseng for Reducing the Blood Pressure in Patients with Hypertension: A Systematic Review and Meta-Analysis / Journal of Ginseng Research 34 (4) : 342 ~ 347
5. [학술지(정기간행물)] - Kim WY / 2000 / Steaming of ginseng at high temperature enhances biological activity / J Nat Prod 63 : 1702 ~ 1704
2. [학술지(정기간행물)] - Adachi M / 2002 / Role of mitochondria in alcoholic liver injury / Free Radic Biol Med 32 : 487 ~ 491
3. [학술지(정기간행물)] - Hyun-Jeong Kim / 2010 / Effects of Fermented Red Ginseng Extracts on Hyperglycemia in Streptozotocin-induced Diabetic Rats / Journal of Ginseng Research 34 (2) : 104 ~ 112
4. [학술지(정기간행물)] - Myung-Haeng Hur / 2010 / Ginseng for Reducing the Blood Pressure in Patients with Hypertension: A Systematic Review and Meta-Analysis / Journal of Ginseng Research 34 (4) : 342 ~ 347
5. [학술지(정기간행물)] - Kim WY / 2000 / Steaming of ginseng at high temperature enhances biological activity / J Nat Prod 63 : 1702 ~ 1704
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UCI(KEPA) : I410-ECN-0101-2013-524-003639889