지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 765 - 777 (13page)
이용수
초록· 키워드
오류제보하기
Objectives : In this study, the author tried to examine whether Gamijinhae-tang and Socheongryong-tang-ga-seokgo significantly affect both PMA-induced mucin production and MUC5AC gene expression from airway epithelial cells.
Materials and Methods : Confluent NCI-H292 cells were pretreated for 30 min in the presence of JHT and STS and treated with PMA (10ng/㎖), to assess the effects of the agents on PMA-induced mucin production by enzyme-linked immunosorbent assay (ELISA). Also, the effects of the agents on PMA-induced MUC5AC gene expression from the same cells were investigated. Possible cytotoxicities of the agent were assessed by examining the rate of survival and proliferation of NCI-H292 cells after treatment of agents during 48 hrs.
Results : (1) JHT and STS did not show significant cytotoxicity to NCI-H292 cells. (2) JHT significantly decreased PMA-induced mucin production from NCI-H292 cells. However, STS did not affect mucin production. (3) JHT significantly inhibit the expression levels of PMA-induced MUC5AC gene in NCI-H292 cells. STS slightly decreased the expression levels of PMA-induced MUC5AC gene.
Conclusion : These results suggest that JHT can not only affect the production of mucin but also affect the expression of the mucin gene, and this explains the traditional use of JHT in oriental medicine. The effects of JHT and STS with their components should be further investigated using animal experimental models that simulate pathophysiology of airway diseases through future studies.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Culpitt SV / 2005 / Sputum matrix metalloproteases: comparison between chronic obstructive pulmonary disease and asthma / Respir Med 99 (6) : 703 ~ 710
Frigas E / 1981 / Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma / Mayo Clin Proc 56 : 345 ~ 353
Gleich GJ. / 1990 / The eosinophil and bronchial asthma Current understanding / J Allergy Clin Immunol 85 : 422 ~ 436
Kim YD / 2002 / Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells / Mol Pharmacol 62 (5) : 1112 ~ 1118
Ko KH / 1999 / Inhibition of mucin release from airway goblet cells by polycationic peptides / Am J Physiol 277 (21) : L811 ~ L815
Frigas E / 1981 / Elevated levels of the eosinophil granule major basic protein in the sputum of patients with bronchial asthma / Mayo Clin Proc 56 : 345 ~ 353
Gleich GJ. / 1990 / The eosinophil and bronchial asthma Current understanding / J Allergy Clin Immunol 85 : 422 ~ 436
Kim YD / 2002 / Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells / Mol Pharmacol 62 (5) : 1112 ~ 1118
Ko KH / 1999 / Inhibition of mucin release from airway goblet cells by polycationic peptides / Am J Physiol 277 (21) : L811 ~ L815
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