지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 526 - 532 (7page)
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Background and Objectives MUC5AC and MUC5B are representative secretory mucin genes in the human airway, whose expressions are increased by a variety of inflammatory mediators. Betulinic acid, a naturally occurring pentacyclic triterpenoid, is known to have an anti-inflammatory property. However, the effects of betulinic acid on mucin secretion of airway epithelial cells still have not been reported. Therefore, in this study, the effect of betulinic acid on inflammatory mediators-induced MUC5AC and MUC5B expressions was investigated in human airway epithelial cells.
Materials and Method In the mucin-producing human NCI-H292 airway epithelial cells, the effects of betulinic acid on interleukin-1β (IL-1β)-, lipopolysaccharide (LPS)-, and phorbol myristate acetate (PMA)-induced MUC5AC and MUC5B expressions were analyzed by reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay.
Results Betulinic acid attenuated IL-1β-, LPS-, and PMA-induced MUC5B mRNA and glycoprotein expression in NCI-H292 cells. On the other hand, betulinic acid did not attenuate IL-1β-, and LPS-, but induced PMA-induced MUC5AC mRNA and glycoprotein expressions in NCI-H292 cells.
Conclusion These results suggest that betulinic acid attenuates IL-1β-, LPS-, and PMA-induced MUC5B expression in the airway epithelial cells. Therefore, betulinic acid may modulate a control of mucus-hypersecretion in airway inflammatory diseases.
Korean J Otorhinolaryngol-Head Neck Surg 2014;57(8):526-32
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참고문헌 (18)
참고문헌 신청
Ali MS / 2007 / Upper airway mucin gene expression: a review / Laryngoscope 117 (5) : 932 ~ 938
Choi JY / 2009 / Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussu
Fisher DE / 1994 / Apoptosis in cancer therapy: crossing the threshold / Cell 78 (4) : 539 ~ 542
Fulda S / 1999 / Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells / Int J Cancer 82 (3) : 435 ~ 441
Kai H / 1994 / Involvement of protein kinase C in mucus secretion by hamster tracheal epithelial cells in culture / Am J Physiol 267 (5 PT 1) : L526 ~ L530
Choi JY / 2009 / Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussu
Fisher DE / 1994 / Apoptosis in cancer therapy: crossing the threshold / Cell 78 (4) : 539 ~ 542
Fulda S / 1999 / Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells / Int J Cancer 82 (3) : 435 ~ 441
Kai H / 1994 / Involvement of protein kinase C in mucus secretion by hamster tracheal epithelial cells in culture / Am J Physiol 267 (5 PT 1) : L526 ~ L530
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