지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제38권 제2호
- 발행연도
- 2008.1
- 수록면
- 395 - 404 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: Osteoprotegerin (OPG) is a secreted glycoprotein and a member of the tumor necrosis factor (TNF) receptor family
that inhibits bone resorption by suppressing osteoclastogenesis. Gingival fibroblasts (GF) play a role in periodontal disease
progression, and the purpose of this experiment was to evaluate influence of osteotropic factors on the expression of
osteoprotegerin mRNA in these cells.
Materials and Methods: In this experiment, the influence of osteoclastogenic factors, interleukin-1 beta (IL-1β), TNF-α,
prostanglandin E2 (PGE2). parathyroid hormone (PTH) and 1α, 25-dihydroxyvitamin D3 on the expression of osteoprotegerin
mRNA in GF was studied by Northern blot hybridization.
Results: As expected, PGE2 tended to inhibit OPG levels and this was most prominent at 24 hours of culture with 10-7M
of PGE2. TNF-α at 10ng/ml and also at 25ng/ml decreased OPG levels to almost 30% of the control at 24 hours. This
contrasts with reports of increased OPG levels from osteoblast/stromal cells and gingival fibroblasts stimulated by TNF-α.
Decrease of OPG levels with PGE2 and TNF-αsuggests a pathway whereby these mediators exert their resorptive effects.
However, OPG levels were increased almost 3-fold at 24 hours with IL-1β(1 to 15ng/ml) and increased 1.4 fold with 24-hour
treatment of 10-7M PTH.
Conclusion: Increase of OPG levels suggests that these ‘osteoclastogenic’ factors act in more complex ways and may act to
inhibit bone resorption in inflammatory periodontitis. This result supports the role of OPG as a negative feedback mechanism
in osteoclastic activity. (J Korean Acad Periodontol 2008;38:395-404)
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Anderson D / 1997 / A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell fuction / Nature 390 : 175 ~ 179
Hofbauer LC / 1999 / Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential par
Hofbauer LC / 2004 / Clinical Implications of the Osteoprotegerin/RANKL/RANK system for bone and vascular Diseases / JAMA 292 : 490 ~ 495
Lacey DL / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93 : 165 ~ 176
Matsuki Y / 1993 / Localization of interleukin-1 mRNA expressing macrophages in human inflamed gingiva and IL-1 activity in gingival crevicu
Hofbauer LC / 1999 / Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential par
Hofbauer LC / 2004 / Clinical Implications of the Osteoprotegerin/RANKL/RANK system for bone and vascular Diseases / JAMA 292 : 490 ~ 495
Lacey DL / 1998 / Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation / Cell 93 : 165 ~ 176
Matsuki Y / 1993 / Localization of interleukin-1 mRNA expressing macrophages in human inflamed gingiva and IL-1 activity in gingival crevicu
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Expression and Regulation of Osteoprotegerin in Adipose Tissue
Yonsei Medical Journal
2007 .01
-
성인 여성에서 혈청 Osteoprotegerin 농도와 골대사의 관련성
대한내과학회지
2004 .01
-
한국인 성인 여성에서 osteoprotegerin 유전자 다형성과 대동맥 석회화의 관련성
대한내과학회지
2006 .01
-
Osteoprotegerin(OPG)-receptor Activator of NF-kB Ligand(RANKL) 유전자 다형성과 전혈세포에서의 OPG, sRANKL 생산 사이의 연관성
OSTEOPOROSIS
2007 .01
-
Transglutaminase-2 Is Involved in Expression of Osteoprotegerin in MG-63 Osteosarcoma Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2013 .01
-
인공관절 주위 골용해에서 관절액의 RANKL/OPG 발현
대한정형외과학회지
2004 .12
-
한국 폐경여성에서 osteoprotegerin (OPG)-receptor activator of NF-kB ligand (RANKL) 유전자 다형성과 호르몬 치료후 골밀도 변화사이의 연관성
Obstetrics & Gynecology Science
2007 .01
-
Salivary soluble receptor activator of nuclear factor kappa B ligand/osteoprotegerin ratio in periodontal disease and health
Journal of Periodontal & Implant Science
2013 .01
-
Effect of Cortical Activation on Mechanical Force-Mediated Changes of OPG and RANKL Levels in Gingival Crevicular Fluid
International Journal of Oral Biology
2009 .01
-
The Effects of Sex Hormones on the Expression of ODF/OPG in Human Gingival Fibroblast and Periodontal Ligament Cell at Serum Concentration During Pregnancy
International Journal of Oral Biology
2005 .01
-
조골세포에서 Rosiglitazone에 의한 RANKL과 OPG의 발현 조절
OSTEOPOROSIS
2010 .01
-
무증상 제2형 당뇨병 환자에서 관상동맥석회 점수와 혈청 osteoprotegerin농도의 상관관계
대한내과학회지
2010 .01
-
The effects of sex hormones on the expression of ODF/OPG in human gingival fibroblast and periodontal ligament cell at normal menstruation cycle and menopause
International Journal of Oral Biology
2007 .01
-
재치환 인공관절 주위 조직에서 Osteoprotegerin [OPG]과 Osteoprotegerin ligand [OPGL]의 발현
대한정형외과학회지
2004 .04
-
골파괴를 동반한 중이진주종에서 RANKL과 OPG mRNA의 발현
대한이비인후-두경부외과학회지
2005 .01
-
Effects of type 2 diabetes mellitus on expression of macrophage colony-stimulating factor and bone differentiation factors in human chronic periodontitis
Oral Biology Research
2012 .01
-
법랑모세포종에서 Receptor Activatorof Nuclear Factor-ĸB Ligand(RANKL)와 Osteoprotegerin(OPG) 발현에 관한 연구
대한구강악안면외과학회지
2007 .01
-
한국 폐경여성에서 골밀도와 Osteoprotegerin 유전자A163G, G1181C 다형성 연구
Obstetrics & Gynecology Science
2003 .01
-
Wnt 길항제 유전자 다형성과 호르몬 치료 후 전혈세포에서의 Osteoprotegerin 및 Soluble Receptor Activator of NF-kB Ligand 생산 변화 양상 사이의 연관성
OSTEOPOROSIS
2012 .01
-
치아발육시기에서의 RANKL 및 OPG의 발현 양상
대한소아치과학회지
2006 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0