골파괴를 동반한 중이진주종에서 RANKL과 OPG mRNA의 발현

여승근; 변재용; 차창일; 김성완; 조중생

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자료유형: 학술저널

저자정보: 여승근 변재용 차창일 김성완 조중생

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제48권 제8호

발행연도: 2005.1

수록면: 955 - 960 (6page)

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Background and Objectives：Bone resorption in middle ear cholesteatoma is mostly responsible for serious complications of the disease, but the pathogenesis of destruction due to bone resorption has not been fully elucidated, although osteoclast activation have been indicated in reports to have a major effect. We have investigated if the receptor activator of NF-κB ligand (RANKL), a cytokine that is arguably the most critical regulator of osteoclast differentiation and activation and its natural inhibitor, osteoprotegerin (OPG), may be important in the bone loss of cholesteatoma. Also, we evaluated the correlation of RANKL and OPG level with the extent of bone destruction. Subjects and Method：A real time RT-PCR was performed to determine and quantify the expression of RANKL and OPG mRNA in 13 cases of cholesteatoma and 8 cases of normal auditory canal skin. Result：1) All cholestatoma and normal external auditory canal skin expressed both mRNA of RANKL and OPG 2) mRNA of RANKL in cholesteatoma were expressed significantly higher than normal external auditory canal skin (p<0.05). 3). The ratio of RANKL to OPG concentration was significantly higher in cholesteatoma than in the normal external auditory canal skin (p<0.05). 4) The ratio of RANKL to OPG was significantly correlated to the extent of bone destruction (p<0.05). Conclusion：These findings suggest the RANKL-OPG loop feedback system is defined in cholesteatoma. RANKL may play a role in the bone destruction ofcholesteatoma. In particular, the balance in the ratio of RANKL to OPG is more important than RANKL

#진주종·RANKL·OPG. #RANKL·OPG·Real time RT-PCR·Cholesteatoma.

참고문헌 (18)

참고문헌 신청

/ 1933 / Role which the epidermis plays in suppuration of the middleear 17 : 488 ~ 502

/ 1984 / Cellular and subcellular events of bone resorption in humanand experimental cholesteatoma:The role of osteoclasts 94 : 76 ~ 95

/ 1996 / Immunohistochemistry & bone resorption. : 36 ~ 48

/ 1998 / Osteoclast differentiation factor mediates an essential signal forbone resorption induced by 1 alpha or parathyroid hormone in the microenvironment ofbone ki ya (sa

/ 1998 / TRANCE is necessaryand sufficient for osteoblast-mediated activation of bone resorption inosteoclasts 188 : 997 ~ 1001

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