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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제6권 제1호
발행연도
2008.1
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24 - 30 (7page)

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Objective：Attention-deficit/hyperactivity disorder (ADHD) is a common, life-long condition associated with major functional impairment, and remission is the primary goal of treatment. The purpose of this study was to identify differences in the clinical characteristics of remission and non-remission groups composed of Korean children and adolescents with ADHD. Methods：Fifty-nine children and adolescents, 6-15 years old, diagnosed with ADHD according to the Diagnostic and Statistical Manual-IV (DSM-IV) criteria were included in the study. The study design was an 8-week, open-label trial of OROSmethylphenidate (OROS-MPH) monotherapy. The subjects were assessed using the Korean ADHD Rating Scale (K-ARS), Clinical Global Impression of Severity (CGI-S), Clinical Global Impression of Improvement (CGI-I), and Barkley Side Effect Rating Scale at baseline and 1, 2, 4, and 8 weeks after starting OROS-MPH treatment. Remission was defined as both a score of ≤2 on the CGI-S and a score of ≤18 on the K-ARS at the eighth week of the trial, when we examined the differences in the clinical characteristics between the remission and non-remission groups. Results：The remission rate at the eighth week was 47.5% (n=28). No differences were observed in the age, sex, weight, severity of symptoms reported by the parent, comorbidities at baseline, or doses of OROS-MPH at each evaluation point between the remission and non-remission groups. However, the non-remission group had higher scores in the CGI-S at baseline than the remission group. A difference in symptom improvement between the two groups began at the first week of the trial, and the remission group was less likely to have side effects at the eighth week. Conclusion：The results suggest that individual biological diversity may mediate different treatment responses to OROS-MPH. Interventions other than medication are needed to achieve remission and to restore proper functioning of patients with ADHD in the nonremission group.
#Atention-deficit/hyperactivity disorder #ADHD) #OROS-methylphe nidate #OROS-MPH) #Remission.

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참고문헌 (21)

참고문헌 신청
[학술지(정기간 google schola / 1994 / Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) / American Psychiatric Association google schola Barkley RA / 1990 / The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up study / J Am Acad Child Adolesc Psychiat google schola Biederman J / 2003 / Pharmacotherapy for attention-deficit/hyperactivity disorder (ADHD) decreases the risk for substance abuse: findingsfrom a longitudinal follow-up of yout google schola Cox DJ / 2004 / Impact of methylphenidate delivery profiles on driving performance of adolescents with attention-deficit/hyperactivity disorder: a pilot study / J Am Acad Chi google schola

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