지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 257 - 262 (6page)
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초록· 키워드
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Objective This study was aimed to determine effectiveness and tolerability of Osmotic-controlled Release Oral delivery (OROS) methylphenidate (MPH) and its optimal dose administered openly over a period of up to 12 weeks in drug naïve Korean children with ADHD.
MethodsaaSubjects (n=143), ages 6 to 18-years, with a clinical diagnosis of any subtype of ADHD were recruited from 7 medical centers in Korea. An individualized dose of OROS-MPH was determined for each subject depending on the response criteria. The subjects were assessed with several symptom rating scales in week 1, 3, 6, 9 and 12.
Results 77 of 116 subjects (66.4%) achieved the criteria for response and the average of optimal daily dose for response was to 30.05±12.52 mg per day (0.90±0.31 mg/kg/d) at the end of the study. Optimal dose was not significantly different between ADHD subtypes, whereas, significant higher dose was needed in older aged groups than younger groups. The average of optimal daily dose for response for the subjects aged above 12 years old was 46.38±15.52 per day (0.81±0.28 mg/kg/d) compared to younger groups (p<0.01). No serious adverse effects were reported and the dose did not have a significant effect on adverse effects.
Conclusion Optimal mean dose of OROS-MPH was significantly different by age groups. Higher dose was needed in older aged groups than younger groups. Effectiveness and tolerability of OROS-MPH in symptoms of ADHD is sustained for up to 12 weeks.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
American Psychiatric Association / 1994 / Diagnostic and Statistical Manual of Mental Disorders / American Psychiatric Association
Angold A. / 1999 / Impaired but undiagnosed / J Am Acad Child Adolesc Psychiatry 38 : 129 ~ 137
Barkley R. / 1990 / The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up styudy / J Am Acad Child Adoles Psychia
Barkley RA. / 1990 / Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation / Pediatrics 86 : 1
Bussing R. / 2003 / Parental explanatory models of ADHD: gender and cultural variations / Soc Psychiatry Psychiatr Epidemiol 38 : 563 ~ 575
Angold A. / 1999 / Impaired but undiagnosed / J Am Acad Child Adolesc Psychiatry 38 : 129 ~ 137
Barkley R. / 1990 / The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up styudy / J Am Acad Child Adoles Psychia
Barkley RA. / 1990 / Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation / Pediatrics 86 : 1
Bussing R. / 2003 / Parental explanatory models of ADHD: gender and cultural variations / Soc Psychiatry Psychiatr Epidemiol 38 : 563 ~ 575
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