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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제38권 제3호
- 발행연도
- 2008.1
- 수록면
- 543 - 550 (8page)
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초록· 키워드
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Purpose: The purpose of this study was to investigate induction of cytokine expression in human gingival fibroblasts (HGFs) by whole cell and the components of T. forsythia.
Material and Methods: After HGFs were treated with lipopolysaccharide (LPS), membrane protein isolated from T. forsythia or culture media of T. forsythia, the induction of interleukin (IL)-1, IL-6 and IL-8 was examined with real-time PCR and ELISA. Their induction ability of cytokines was compared with whole bacteria.
Result: The expression of IL-6 and IL-8 was significantly induced in HGFs by whole bacteria and membrane protein. The expression of IL-1β was induced by membrane protein of T. forsythia, not by whole bacteria. LPS and condition media of T. forsythia slightly activated HGFs.
Conclusion: The membrane protein of T. forsythia could be one of virulence factors. (J Korean Acad Periodontol 2008;38:543-550)
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참고문헌 (23)
참고문헌 신청
Bodet C / 2006 / Inflammatory responses of a macrophage/epithelial cell co-culture model to mono and mixed infections with Porphyromonas gingivalis, Treponema denticola, and
Hajishengallis G / 2002 / Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction / Clin Diagn Lab Immunol 9 : 403 ~ 411
Hasebe A / 2004 / Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease / Infect Immun 72 : 1318 ~ 1325
Ikegami A / 2004 / Multiple functions of the leucine-rich repeat protein LrrA of Treponema denticola / Infect Immun 72 : 4619 ~ 4627
Into T / 2002 / Mycoplasmal lipoproteins induce toll-like receptor 2- and caspases-mediated cell death in lymphocytes and monocytes / Microbiol Immunol 46 : 265 ~ 276
Hajishengallis G / 2002 / Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction / Clin Diagn Lab Immunol 9 : 403 ~ 411
Hasebe A / 2004 / Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease / Infect Immun 72 : 1318 ~ 1325
Ikegami A / 2004 / Multiple functions of the leucine-rich repeat protein LrrA of Treponema denticola / Infect Immun 72 : 4619 ~ 4627
Into T / 2002 / Mycoplasmal lipoproteins induce toll-like receptor 2- and caspases-mediated cell death in lymphocytes and monocytes / Microbiol Immunol 46 : 265 ~ 276
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