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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제3호
- 발행연도
- 2018.1
- 수록면
- 253 - 261 (9page)
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Objective: The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans. Methods: Eleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg, or placebo (PLA) at 9:00 PM in a double blind, randomized, controlled, repeated measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed. Results: A repeated measures multivariate analysis of variance revealed a significant main effect for the factor condition (AMI, ESC, PLA). Subsequent univariate analyses demonstrated significant condition effects for ghrelin and cortisol. Post-hoc analyses demonstrated a significant reduction of ghrelin levels after AMI in comparison to PLA, and a significant reduction of cortisol levels after AMI in comparison to both ESC and PLA. Other contrasts did not reach statistical significance. Conclusion: Administration of a single dose of AMI, but not of ESC, leads to a significant reduction in morning serum ghrelin and cortisol levels. No effects on leptin and prolactin levels were observed. The differential impact of AMI and ESC on hormones might contribute to different adverse effect profiles of both substances.
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참고문헌 (44)
참고문헌 신청
Gayetot D / 2007 / When depression does not end. Resistant depression: recent clinical and therapeutic aspects / Rev Med Liege 62:103~111
Lohse MJ / 2015 / Psychopharmaka;Arzneiverordnungs-Report 2015: Aktuelle Daten, Kosten, Trends und Kommentare :939~981
Halford JC / 2011 / Serotonergic anti-obesity agents: past experience and future prospects / Drugs 71:2247~2255
Ferguson JM / 2001 / SSRI Antidepressant medications: adverse effects and tolerability / Prim Care Companion J Clin Psychiatry 3:22~27
Kanoski SE / 2017 / Hippocampus contributions to food intake control: Mnemonic, neuroanatomical, and endocrine mechanisms / Biol Psychiatry 81:748~756
Lohse MJ / 2015 / Psychopharmaka;Arzneiverordnungs-Report 2015: Aktuelle Daten, Kosten, Trends und Kommentare :939~981
Halford JC / 2011 / Serotonergic anti-obesity agents: past experience and future prospects / Drugs 71:2247~2255
Ferguson JM / 2001 / SSRI Antidepressant medications: adverse effects and tolerability / Prim Care Companion J Clin Psychiatry 3:22~27
Kanoski SE / 2017 / Hippocampus contributions to food intake control: Mnemonic, neuroanatomical, and endocrine mechanisms / Biol Psychiatry 81:748~756
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