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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제4호
- 발행연도
- 2018.1
- 수록면
- 361 - 375 (15page)
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We aimed to compare the efficacy and safety of long-acting injectable (LAI) and oral second-generation antipsychotics (SGAs) in treating schizophrenia by performing a systematic review and meta-analysis. MEDLINE, EMBASE, PsycINFO, CINAHL, and the Cochrane Library, as well as five Korean databases, were systemically searched to identify studies published from 2000 to 16 April 2015, which compared the efficacy and safety of LAI and oral SGAs. Using data from randomized controlled trials (RCTs), meta-analyses were conducted. In addition, the GRADE (the Grading of Recommendations, Assessment, Development and Evaluation) approach was applied to explicitly assess the quality of the evidence. A total of 30 studies including 17 RCTs and 13 observational studies were selected. The group treated with LAI SGAs was characterized by significantly lower relapse rates, longer times to relapse and fewer hospital days, but also by a higher occurrence of extrapyramidal syndrome and prolactin-related symptoms than that in the group treated with oral SGAs. Our findings demonstrate that there is moderate to high level of evidence suggesting that in the treatment of schizophrenia, LAI SGAs have higher efficacy and are associated with higher rates of extrapyramidal syndrome and prolactin-related symptoms. Additionally, the use of LAI SGAs should be combined with appropriate measures to reduce dopamine D2 antagonism-related symptoms.
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참고문헌 (3)
참고문헌 신청
Filiz Karadag / 2017 / Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders / Clinical Psychopharmacology and Neuroscience 15(2):153~162
Adarsh Tripathi / 2018 / Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies / Clinical Psychopharmacology and Neuroscience 16(1):7~17
Manchanda R / 2013 / Long-acting injectable antipsychotics: evidence of effectiveness and use / Can J Psychiatry 58(5 Suppl 1):5S~13S
Adarsh Tripathi / 2018 / Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies / Clinical Psychopharmacology and Neuroscience 16(1):7~17
Manchanda R / 2013 / Long-acting injectable antipsychotics: evidence of effectiveness and use / Can J Psychiatry 58(5 Suppl 1):5S~13S
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