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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 1 - 9 (9page)
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Objective: To investigate the effect of environmental enrichment on the cognitive and motor development in the experimental hypoxia-ischemic encephalopathy neonatal rat model.
Method: Hypoxic-ischemic encephalopathy models were made in neonatal Sprague-Dawley rats at 3 days of age by ligating the unilateral carotid artery followed by inhalation of 8% oxygen and raised in the enriched environment (n=10), treadmill exercise (n=8) and non-stimulation (n=10) from the 3rd to 8th weeks of age. Neurobehavioral and histopathological changes were compared.
Results: The neurobehavioral tests of the rats with hypoxic- ischemic encephalopathy showed prolonged latencies of achievement for cliff avoidance and negative geotaxis (p＜0.05). Persisting abnormality into adult life of limb placing improved in exercise and enriched environment groups and spatial learning and memory in a water maze recovered in the rats with enriched environment (p＜0.05). The density of dendritic spine increased in the hippocampus with enriched environment (p＜0.05).
Conclusion: The present study supports the possibilities of the positive effects after the enriched environment in the developing brain with hypoxic injury. (J Korean Acad Rehab Med 2010; 34: 1-9)
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참고문헌 (25)
참고문헌 신청
Balduini W / 2000 / Long- lasting behavioral alterations following a hypoxic/ischemic brain injury in neonatal rats / Brain Res 859 : 318 ~ 325
Bona E / 1997 / Sensorimotor function and neuropathology five to six weeks after hypoxia-ischemia in seven-day-old rats / Pediatr Res 42 : 678 ~ 683
Bryan GK / 1989 / Deprived somatose
Ferchmin PA / 1986 / Forty minutes of experience increase the weight and RNA content of cerebral cortex in periadolescent rats / Dev Psychobiol 19 : 511 ~ 519
Franck LS / 1991 / Dissociation of antinociceptive and motor effects of supraspinal opioid agonists in the rat / Brain Res 563 : 123 ~ 126
Bona E / 1997 / Sensorimotor function and neuropathology five to six weeks after hypoxia-ischemia in seven-day-old rats / Pediatr Res 42 : 678 ~ 683
Bryan GK / 1989 / Deprived somatose
Ferchmin PA / 1986 / Forty minutes of experience increase the weight and RNA content of cerebral cortex in periadolescent rats / Dev Psychobiol 19 : 511 ~ 519
Franck LS / 1991 / Dissociation of antinociceptive and motor effects of supraspinal opioid agonists in the rat / Brain Res 563 : 123 ~ 126
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