지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 331 - 339 (9page)
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초록· 키워드
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Objective To investigate the effects of aerobic exercise on neuropathic pain and verify whether regular treadmill exercise alters opioid receptor expression in the rostral ventral medulla (RVM) in a neuropathic pain rat model.Methods Thirty-two male Sprague-Dawley rats were used in the study. All rats were divided into 3 groups, i.e., group A, sham group (n=10); group B, chronic constriction injury (CCI) group (n=11); and group C, CCI+exercise group (n=11). Regular treadmill exercise was performed for 30 minutes a day, 5 days a week, for 4 weeks at the speed of 8 m/min for 5 minutes, 11 m/min for 5 minutes, and 22 m/min for 20 minutes. Withdrawal threshold and withdrawal latency were measured before and after the regular exercise program. Immunohistochemistry and Western blots analyses were performed using antibodies against μ-opioid receptor (MOR).Results Body weight of group C was the lowest among all groups. Withdrawal thresholds and withdrawal latencies were increased with time in groups B and C. There were significant differences of withdrawal thresholds between group B and group C at 1st, 2nd, 3rd, and 4th weeks after exercise. There were significant differences of withdrawal latencies between group B and group C at 3rd and 4th weeks after exercise. MOR expression of group C was significantly decreased, as compared to that of group B in the RVM and spinal cord.Conclusion In neuropathic pain, exercise induced analgesia could be mediated by desensitization of central MOR by endogenous opioids, leading to the shift of RVM circuitry balance to pain inhibition.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Bennett GJ / 1988 / A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man / Pain 33 : 87 ~ 107
Bennett GJ / 1989 / Processing of sensory information in the superficial dorsal horn of the spinal cord / Plenum Press : 463 ~ 471
Chaplan SR / 1994 / Quantitative assessment of tactile allodynia in the rat paw / J Neurosci Methods 53 : 55 ~ 63
Costigan M / 2009 / Neuropathic pain: a maladaptive response of the nervous system to damage / Annu Rev Neurosci 32 : 1 ~ 32
De Oliveira MS / 2010 / Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats / Brain Res Bull 83 : 278 ~ 283
Bennett GJ / 1989 / Processing of sensory information in the superficial dorsal horn of the spinal cord / Plenum Press : 463 ~ 471
Chaplan SR / 1994 / Quantitative assessment of tactile allodynia in the rat paw / J Neurosci Methods 53 : 55 ~ 63
Costigan M / 2009 / Neuropathic pain: a maladaptive response of the nervous system to damage / Annu Rev Neurosci 32 : 1 ~ 32
De Oliveira MS / 2010 / Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats / Brain Res Bull 83 : 278 ~ 283
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