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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 180 - 181 (2page)
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Dear Editor, We would like to thank Bennett JM and Wells DA for their insightful comments [1] regarding our manuscript “Lee et al. An unusual case of myeloperoxidase-positive acute megakaryoblastic leukemia. Ann Lab Med 2015;35:466-8” [2]. The case that we reported was diagnostically challenging, and our conclusions were based on various lines of evidence. In particular, the morphological features of blasts were unusual. Most of the blasts were similar to those of acute myeloid leukemia with or without maturation, but some blasts had multiple, clear cytoplasmic projections. In the immunophenotyping study, a similar proportion (approximately 57%) of blasts showed positivity for myeloperoxidase (MPO) and CD41a. We initially considered the possibility of false-positive CD41a expression because of platelet contamination. However, the CD41a-positive population was mainly in the blast population, and not in the platelets, as demonstrated in the backgating analysis (Fig. 1). Accordingly, we concluded that blasts exhibited true positivity of CD41a expression. We have about 25 yr of experience with flow cytometry, including more than 1,000 cases of newly diagnosed acute leukemia. Nonetheless, this was our first observation of blasts that coexpressed MPO and CD41a. We could not find appropriate diagnostic criteria for this case. Considering previously reported cases, we concluded that this case was MPO-positive acute megakaryoblastic leukemia (AMKL).
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참고문헌 (7)
참고문헌 신청
John M. Bennett / 2015 / Re: Lee H, et al. An Unusual Case of Myeloperoxidase-Positive Acute Megakaryoblastic Leukemia. Ann Lab Med 2015;35:466-8 / Annals of Laboratory Medicine 35(5):542~543
이혜영 / 2015 / An Unusual Case of Myeloperoxidase-Positive Acute Megakaryoblastic Leukemia / Annals of Laboratory Medicine 35(4):466~468
Tallman MS / 2000 / Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience / Blood 96:2405~2411
Majhi U / 2012 / Megakaryoblastic leukemia presenting as pancytopenia and extensive myelofibrosis in a child diagnosed by myeloid markers and CD 31 / Indian J Med Paediatr Oncol 33:59~61
Barbui T / 2012 / How to manage children and young adults with myeloproliferative neoplasms / Leukemia 26:1452~1457
이혜영 / 2015 / An Unusual Case of Myeloperoxidase-Positive Acute Megakaryoblastic Leukemia / Annals of Laboratory Medicine 35(4):466~468
Tallman MS / 2000 / Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience / Blood 96:2405~2411
Majhi U / 2012 / Megakaryoblastic leukemia presenting as pancytopenia and extensive myelofibrosis in a child diagnosed by myeloid markers and CD 31 / Indian J Med Paediatr Oncol 33:59~61
Barbui T / 2012 / How to manage children and young adults with myeloproliferative neoplasms / Leukemia 26:1452~1457
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