지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 477 - 482 (6page)
이용수
초록· 키워드
오류제보하기
Objective: This study was designed to investigate the mechanism of the primary afferent input to spread of contralateral hyperalgesia in the persistent muscle pain model in the rat.
Method: Muscle pain was induced by twice repeated intramuscular injections of pH 6.0 buffered saline into the unilateral gastrocnemius muscle of the rats. Change of mechanical withdrawal threshold to von-Frey filament was measured after ipsilateral laser irradiation, anesthetic blockade with lidocaine and dorsal rhizotomy (L2～L6) to reduce primary afferent input from the tissue injury.
Results: Bilateral persistent mechanical hyperalgesia in the hind paw was evoked after second injection. Ipsilateral laser irradiation, lidocaine injection and dorsal rhizotomy had no effect on the contralateral spread of mechanical hyperalgesia.
Conclusion: These results suggest that contralateral hyperalgesia was produced by, but didn't need to be maintained by inputs from an injury. Therefore, central nervous systems are responsible for the contralateral spread of hyperalgesia.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
/ 1983 / Relief from chronic pain by low power laser irradiation 43 : 339 ~ 344
/ 1985 / Increased pain sensitivity following heat injury involves a central mechanism 15 : 259 ~ 262
/ 1985 / Reflex neurogenic inflammation:Contribution of the peripheral nervous system to spatially remote inflammatory responses that follow injury 5 : 1380 ~ 1386
/ 1987 / Cutaneous hyperalgesia:contribution of the peripheral and central nervous systems to the increase in pain sensitivity after injury 404 : 95 ~ 106
/ 1990 / Evidence for a central component in the sensitization of spinal neurons with joint input during development of acute arthritis in cat's knee 64 : 299 ~ 311
/ 1985 / Increased pain sensitivity following heat injury involves a central mechanism 15 : 259 ~ 262
/ 1985 / Reflex neurogenic inflammation:Contribution of the peripheral nervous system to spatially remote inflammatory responses that follow injury 5 : 1380 ~ 1386
/ 1987 / Cutaneous hyperalgesia:contribution of the peripheral and central nervous systems to the increase in pain sensitivity after injury 404 : 95 ~ 106
/ 1990 / Evidence for a central component in the sensitization of spinal neurons with joint input during development of acute arthritis in cat's knee 64 : 299 ~ 311
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