지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 682 - 688 (7page)
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초록· 키워드
오류제보하기
Objective To evaluate the analgesic effect of intrathecal gabapentin therapy on secondary hyperalgesia in a rat model of persistent muscle pain.Methods Intrathecal catheters were implanted into rats. Mechanical secondary hyperalgesia was induced by repeated intramuscular injections of acidic solution into the gastrocnemius muscle. Gabapentin was administrated intrathecally. Rats were allocated to control and experimental (gabapentin 30, 100, 300, and 1,000 mg) group. After gabapentin administration, mechanical withdrawal threshold was measured every 15 minutes and the motor function was measured 30 minutes later.Results Mechanical hyperalgesia was evoked after the second acidic buffer injection. There was a significant improvement on the mechanical threshold after administration of 100, 300, and 1,000 mg gabapentin compared to pre-injection and the control group. The analgesic effect continued for 105, 135, and 210 minutes, respectively. To discern side effects, motor function was measured. Motor function was preserved in both groups after gabapentin administration, except for rats who received 1,000 mg gabapentin.Conclusion Intrathecal gabapentin administration produces dose-dependent improvements in mechanical hyperalgesia in a persistent muscle pain rat model. This implicates the central nervous system as having a strong influence on the development of persistent mechanical hyperalgesia. These results are helpful in understanding the pathophysiology of secondary hyperalgesia and in the treatment of patients with chronic muscle pain.
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참고문헌 (25)
참고문헌 신청
Ankesh Kukkar / 2013 / Implications and mechanism of action of gabapentin in neuropathic pain / Archives of Pharmacal Research 36 (3) : 237 ~ 251
Backonja M / 1998 / Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial / JAMA 280 : 1831 ~ 1836
Bockbrader HN / 2010 / A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin / Clin Pharmacokinet 49 : 661 ~ 669
Bone M / 2002 / Gabapentin in postamputation phantom limb pain: a randomized, double-blind, placebo-controlled, cross-over study / Reg Anesth Pain Med 27 : 481 ~ 486
Chaplan SR / 1994 / Quantitative assessment of tactile allodynia in the rat paw / J Neurosci Methods 53 : 55 ~ 63
Backonja M / 1998 / Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial / JAMA 280 : 1831 ~ 1836
Bockbrader HN / 2010 / A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin / Clin Pharmacokinet 49 : 661 ~ 669
Bone M / 2002 / Gabapentin in postamputation phantom limb pain: a randomized, double-blind, placebo-controlled, cross-over study / Reg Anesth Pain Med 27 : 481 ~ 486
Chaplan SR / 1994 / Quantitative assessment of tactile allodynia in the rat paw / J Neurosci Methods 53 : 55 ~ 63
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