지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 590 - 594 (5page)
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초록· 키워드
오류제보하기
Soluble suppression of tumorigenicity 2 (sST2) has emerged as a biomarker of cardiac stretch or remodeling, and has demonstrated a role in acutely decompensated heart failure. However, its role in sepsis-induced cardiac dysfunction is still unknown. We explored whether sST2 serum concentration reflects either systolic or diastolic dysfunction as measured by Doppler echocardiography. In a total of 127 patients with sepsis, correlations between sST2 and blood pressure, left ventricular (LV) ejection fraction, LV diastolic filling (ratio of early transmitral flow velocity to early diastolic mitral annulus velocity), and resting pulmonary arterial pressure were evaluated. Correlations between sST2 and other sepsis biomarkers (high-sensitivity C-reactive protein [hs-CRP] and procalcitonin) were also examined. sST2 showed a moderate correlation with mean arterial pressure (r=-0.3499) but no correlation with LV ejection fraction, diastolic filling, or resting pulmonary hypertension. It showed moderate correlations with hs-CRP and procalcitonin (r=0.2608 and r=0.3829, respectively). sST2 might have a role as a biomarker of shock or inflammation, but it cannot reflect echocardiographic findings of LV ejection fraction or diastolic filling in sepsis.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Singer M / 2016 / The third international consensus definitions for sepsis and septic shock (Sepsis-3) / JAMA 315:801~810
Dellinger RP / 2013 / Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012 / Crit Care Med 41:580~637
Weir RA / 2010 / Serum soluble ST2: a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction / J Am Coll Cardiol 55:243~250
Januzzi JL / 2015 / ST2 and prognosis in acutely decompensated heart failure: the International ST2 Consensus Panel / Am J Cardiol 115(7 Suppl):26B~31B
Brunner M / 2004 / Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma / Intensive Care Med 30:1468~1473
Dellinger RP / 2013 / Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012 / Crit Care Med 41:580~637
Weir RA / 2010 / Serum soluble ST2: a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction / J Am Coll Cardiol 55:243~250
Januzzi JL / 2015 / ST2 and prognosis in acutely decompensated heart failure: the International ST2 Consensus Panel / Am J Cardiol 115(7 Suppl):26B~31B
Brunner M / 2004 / Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma / Intensive Care Med 30:1468~1473
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