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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 585 - 590 (6page)
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In B lymphoblastic leukemia/lymphoma (B-ALL/LBL), t(9;22)(q34;q11.2) and t(1;19)(q23;p13.3) are recurrent cytogenetic abnormalities. The concurrent occurrence of both abnormalities is very rare, and only 3 cases have been previously reported. Here, we report a case of adult B-ALL with ider(9)(q10)t(9;22)(q34;q11.2) and der(19)t(1;19)(q23;p13.3). A literature review revealed that ider(9) (q10)t(9;22) is a rare variant of t(9;22) with a deletion of the short arm of chromosome 9. Fifteen cases of ider(9)(q10)t(9;22) have been reported. This abnormality is specific to precursor B-lymphoid neoplasms,such as B-ALL or B-lymphoid blast phase of CML, and is associated with disease progression or short survival. The cytogenetic abnormality t(1;19) is also specific to B-ALL. In most instances of t(1;19), TCF3 is fused to PBX1; however, a few cases have identical translocations but no TCF3-PBX1 fusion, as was observed in our patient. We describe the first case of ider(9)(q10)t(9;22) in combination with TCF3-PBX1 negative t(1;19). The patient underwent imatinib therapy in addition to intensive chemotherapy, but failed to achieve remission. (Korean J Lab Med 2010;30:585-90)
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Barber KE / 2007 / Molecular cytogenetic characterization of TCF3 (E2-A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia / Genes Chromosomes Cancer 46:478~486
Boomer T / 2001 / Detection of E2A translocations in leukemias via fluorescence in situ hybridization / Leukemia 15:95~102
Pui CH / 1994 / Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t(1;19) (q23;p13) or its derivative / J Clin Oncol 12:2601~2606
Griffin TC / 1992 / Rosenfield C, et al. Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22) / Leukemia 6:535~540
Anastasi J / 1995 / The relationship between secondary chromosomal abnormalities and blast transformation in chronic myelogenous leukemia / Leukemia 9 : 628 ~ 633
Boomer T / 2001 / Detection of E2A translocations in leukemias via fluorescence in situ hybridization / Leukemia 15:95~102
Pui CH / 1994 / Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t(1;19) (q23;p13) or its derivative / J Clin Oncol 12:2601~2606
Griffin TC / 1992 / Rosenfield C, et al. Childhood acute lymphoblastic leukemia with both t(1;19) and t(9;22) / Leukemia 6:535~540
Anastasi J / 1995 / The relationship between secondary chromosomal abnormalities and blast transformation in chronic myelogenous leukemia / Leukemia 9 : 628 ~ 633
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