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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 255 - 259 (5page)
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초록· 키워드
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ALL with MLL gene rearrangement secondary to chemotherapy has been rarely reported. We report a case of therapy-related ALL (t-ALL) with MLL gene rearrangement in a patient who had undergone treatment for breast cancer. A 60-yr-old woman with breast cancer underwent breastconserving surgery followed by 6 cycles of adjuvant chemotherapy (cyclophosphamide, epirubicin, and fluorouracil) and radiation therapy (dose, 5,040 cGy to the left breast and a 1,000 cGy boost to the tumor bed). A follow-up examination performed 14 months after the chemotherapy revealed no evidence of breast malignancy. However, the patient’s complete blood cell count indicated acute leukemia: white blood cell count, 174.1×109/L with 88% blasts; Hb level, 12.5 g/dL; and platelet count, 103.0×109/L. Examination of the bone marrow aspirate smear revealed a high percentage of blasts (85.1% of all nucleated cells); the blasts showed a pro-B immunophenotype and were positive for CD19, CD79a, HLA-DR, CD34, and terminal deoxynucleotidyl transferase (TdT). Cytogenetic and FISH analyses revealed t(4;11)(q21;q23) and MLL gene rearrangement, respectively. The patient received induction chemotherapy with cyclophosphamide, vincristine, doxorubicin, and dexamethasone and achieved complete remission. Following consolidation chemotherapy, she underwent allogenic peripheral blood stem cell transplantation and has been clinically stable. To our knowledge, this is the first reported case of t-ALL with MLL gene rearrangement following treatment of breast cancer in Korea. (Korean J Lab Med 2010;30:255-9)
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Andersen MK / 2001 / Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new
Hrusak O / 2002 / Antigen expression patterns reflecting genotype of acute leukemias / Leukemia 16 : 1233 ~ 1258
Ishizawa S / 2003 / High frequency of pro-B ALL in adults with secondary leukemia with 11q23 abnormalities / Leukemia 17 : 1091 ~ 1095
Kim M / 2006 / A case of therapy-related AML associated with inv(16), with subsequent development of t(9;22) / Leukemia 20 : 746 ~ 748
Lee SG / 2009 / Therapy-related ALL with t(9;22)(q34;q11.2):a case study and review of the literature / Cancer Genet Cytogenet 191 : 51 ~ 54
Hrusak O / 2002 / Antigen expression patterns reflecting genotype of acute leukemias / Leukemia 16 : 1233 ~ 1258
Ishizawa S / 2003 / High frequency of pro-B ALL in adults with secondary leukemia with 11q23 abnormalities / Leukemia 17 : 1091 ~ 1095
Kim M / 2006 / A case of therapy-related AML associated with inv(16), with subsequent development of t(9;22) / Leukemia 20 : 746 ~ 748
Lee SG / 2009 / Therapy-related ALL with t(9;22)(q34;q11.2):a case study and review of the literature / Cancer Genet Cytogenet 191 : 51 ~ 54
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