지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 208 - 214 (7page)
이용수
초록· 키워드
오류제보하기
Purpose The 21-gene (Oncotype DX) recurrence score (RS) assay is useful in predicting the benefitsof adjuvant chemotherapy for early breast cancer patients and is widely used in Westerncountries. However, to date, it has not gained much popularity in East Asia. We analyzedthe results from five institutions’ experience from using the 21-gene assay and examinedthe impact of assay results on decision making of chemotherapy in Korean breast cancerpatients and the associations between RS and clinicopathologic characteristics.
Materials and MethodsThe 21-gene assay was performed on 212 patients with estrogen receptor-positive earlybreast cancer in five institutions. Each center made systemic treatment decisions bothbefore and after the knowledge of assay results.
ResultsAmong the 212 patients, 132 (62.3%) had a low RS of < 18, 60 (28.3%) had an intermediateRS of 18-30, and 20 (9.4%) had a high RS of ! 31. Histologic grade, presence ofmicrometastases, Ki-67, and presence of lymphatic invasion were statistically associatedwith the RS results. Treatment decisions were changed in 115 of 212 patients (54.2%) in109 of 212 (51.4%) from chemotherapy plus hormone therapy to hormone therapy, and insix of 212 (2.8%) from hormone therapy to chemotherapy plus hormone therapy.
ConclusionThe 21-gene breast cancer assay proved to have a significant impact on treatment decision-making. The test reduces chemotherapy use in more than 50% of Korean estrogenreceptor-positive, early breast cancer patients.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Ademuyiwa FO / 2011 / The effects of oncotype DX recurrence scores on chemotherapy utilization in a multi-institutional breast cancer cohort / Breast Cancer Res Treat 126 :
Aebi S / 2011 / Primary breastcancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up / Ann Oncol 22 (Suppl 6) : 12 ~ 24
Albanell J / 2012 / Prospective transGEICAM study of the impact of the 21-gene Recurrence Score assay and traditional clinicopathological factors on adjuvant clinical decisi
Asad J / 2008 / Does oncotype DX recurrence score affect the management of patients with early-stage breast cancer? / Am J Surg 196 : 527 ~ 529
Biroschak JR / 2013 / Impact of Oncotype DX on treatment decisions in ER-positive, node-negative breast cancer with histologic correlation / Breast J 19 : 269 ~ 275
Aebi S / 2011 / Primary breastcancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up / Ann Oncol 22 (Suppl 6) : 12 ~ 24
Albanell J / 2012 / Prospective transGEICAM study of the impact of the 21-gene Recurrence Score assay and traditional clinicopathological factors on adjuvant clinical decisi
Asad J / 2008 / Does oncotype DX recurrence score affect the management of patients with early-stage breast cancer? / Am J Surg 196 : 527 ~ 529
Biroschak JR / 2013 / Impact of Oncotype DX on treatment decisions in ER-positive, node-negative breast cancer with histologic correlation / Breast J 19 : 269 ~ 275
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Omission of Chemotherapy for Hormone Receptor Positive and Her2-negative Breast Cancer: Patterns of Treatment and Outcomes from The Korean Breast Cancer Registry
대한외과학회 학술대회 초록집
2020 .11
-
Assessment genomic risk of high Ki67 (≥20%) ER+HER2-breast cancer using 21-gene multigene assay (Oncotype DX)
대한임상종양학회 학술대회지
2022 .02
-
Comparison of the Beneficial Effects of Adjuvant Chemotherapy among Young and Old Aged Breast Cancer Patients
Journal of Breast Disease
2019 .01
-
The 21-Gene Recurrence Score Assay Improved Multidisciplinary Treatment Compliance in Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Patients: An Analysis of 2,323 Patients
Journal of Breast Cancer
2024 .06
-
Breast cancer
대한외과학회 학술대회 초록집
2015 .11
-
Breast Cancer
대한외과학회 학술대회 초록집
2022 .11
-
Breast Cancer
대한외과학회 학술대회 초록집
2020 .11
-
Tp53 Mutation Is Linked with High 21-Gene Recurrence Score in ER+/HER2- Breast Cancer
대한외과학회 학술대회 초록집
2021 .05
-
Breast Cancer
대한외과학회 학술대회 초록집
2020 .11
-
Predictive Factors of Pathologic N2/N3 Disease in Clinical or Pathologic N1 ER+/HER2- Breast Cancer
대한외과학회 학술대회 초록집
2023 .05
-
Breast Cancer
대한외과학회 학술대회 초록집
2019 .10
-
Breast Cancer
대한외과학회 학술대회 초록집
2022 .11
-
Early-Stage Breast Cancer in the Elderly: Confronting an Old Clinical Problem
Journal of Breast Cancer
2015 .01
-
유방암에 대한 한양방 병용 치료 증례 보고 1례
대한한방내과학회지
2017 .01
-
Guidelines on hormone therapy in breast cancer
대한외과학회 학술대회 초록집
2016 .11
-
A comparative study of the clinical characteristics and outcomes of hormone receptor positive, HER2 negative breast cancer patients over 65 years old and under 65 years old patients
대한임상종양학회 학술대회지
2020 .07
-
Neoadjuvant Chemotherapy versus Adjuvant Chemotherapy in Breast Cancer Patients: Analysis of Breast Conserving Rate and De-escalation of Axillary Surgery in 5141 Korean Women
대한외과학회 학술대회 초록집
2020 .11
-
The Basic Facts of Korean Breast Cancer in 2012: Results from a Nationwide Survey and Breast Cancer Registry Database
Journal of Breast Cancer
2015 .01
-
Chemotherapy and Radiation Treatment for Breast Reconstruction Patients
대한외과학회 학술대회 초록집
2019 .10
-
Prognostic Value of Chemotherapy-Induced Amenorrhea in Breast Cancer: a Meta-Analysis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0