건강한 여성 근로자에서 Apolipoprotein E와 혈중 지질 농도와의 관련성

문기은; 성숙희; 장윤균; 박일근; 백윤미; 김수근; 최태인; 진영우

추천

검색

자료유형: 학술저널

저자정보: 문기은 성숙희 장윤균 박일근 백윤미 김수근 최태인 진영우

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제43권 제3호

발행연도: 2010.1

수록면: 213 - 221 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objectives: Plasma lipid profiles and Apolipoprotein E (ApoE) are established risk factors for cardiovascular disease (CVD). The knowledge of lipid profile may estimate the potential victims of cardiovascular disease before its initiation and progression and offers the opportunity for primary prevention. The most common ApoE polymorphism has been found to influence plasma lipid concentrations and its correlation with CVD has been extensively investigated in the last decade. Methods: The ApoE polymorphism and its influence on plasma lipid were investigated in healthy woman workers. The information on confounding factors was obtained through a self-administered questionnaire and ApoE polymorphism was investigated using PCR. Results: The relative frequencies of alleles E2, E3 and E4 for the study population (n = 305) were 0.127, 0.750 and 0.121,respectively. ApoE polymorphism was associated with variations in plasma HDL-cholesterol lipid profile. In order to estimate the independent effects of alleles E2 and E4, as compared with E3, on lipid profile, multiple regression was performed after adjustment for confounding variables such as age, BMI, blood pressure, education status, insulin, fasting glucose, HOMA-IR,menopause. ApoE2 had a negative association with HDL cholesterol and ApoE4 had a positive association with LDL cholesterol. Conclusions: This study identified that the ApoE and CVD risk factors contribute to the lipid profiles, similar to other studies. The analysis including dietary intake and other gene in further studies may help to identify clear effects on lipid profiles as risk factor for CVD.

#Apolipoprotein E #Cardiovascular disease #Cholesterol #Triglyceride #Koreans #Women's health

참고문헌 (24)

참고문헌 신청

American Heart Association / / American Heart Association.Women and cardiovascular diseases:statistics.Statistical fact sheet-populations [cited 2009 Nov 23] Available from:URL

Bednarska-Makaruk M / 2001 / Apolipoprotein E genotype, lipid levels and coronary heart disease in a Polish population group / Eur J Epidemiol 17 (8) : 789 ~ 792

Boorsma W / 2008 / Body composition, insulin sensitivity, and cardiovascular disease profile in healthy Europeans / Obesity 16 (12) : 2696 ~ 2701

Despres JP / 2000 / HDL-cholesterol as a marker of coronary heart disease ris

Frayn KN / 2005 / Diet, Nutrition and Emerging Risk Factors. The Report of a British Nutrition Foundation Task Force / Blackwell Publishing

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!