지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 429 - 434 (6page)
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Purpose: We investigated how serum low-density lipoprotein (LDL) level is related to various isoforms of apolipoprotein (ApoE) polymorphism in association with obesity and metabolic syndrome. Materials and Methods: We gathered total 332 sample of postmenopausal Korean women and analyzed ApoE isoforms, serum lipid level including LDL, blood pressure, fasting glucose, and anthropometry. The relationship between ApoE isoforms and serum lipid level, metabolic syndrome, and obesity was investigated. Results: Six ApoE isoforms were found, ApoE2 [E2/2 (n=1), E2/3 (n=54), E2/4 (n=14)], ApoE3 (E3/3, n=200), ApoE4 [E3/4 (n=55), and E4/4 (n=8)]. The prevalence of metabolic syndrome and obesity showed higher ApoE3 isoform than that of other isoforms. In additon, ApoE3 isoform was related to higher serum LDL and total cholesterol level than to ApoE2 isoform. The odds ratio of having the highest LDL cholesterol quartile in ApoE3 with obesity, compared to ApoE2 without obesity, was 3.46 [95% confidence interval (CI); 1.07-11.14, p=0.037], and odds ratio of ApoE3 with metabolic syndrome compared to ApoE2 without metabolic syndrome was 5.06 (95% CI; 1.14-22.29, p=0.037). Serum LDL cholesterol was positively associated with obesity or metabolic syndrome in ApoE3 isoform. Conclusion: This study suggests that obesity or metabolic syndrome risk should be effectively managed in ApoE3 isomform groups to reduce serum LDL in postmenopausal Korean women.
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참고문헌 (24)
참고문헌 신청
/ / The Asia-Pacific perspective: redefining obesity and its treatment / 2000 Feb. Sponsored by the Regional Office for the Western Pacific WPRO), World Health Organization, the I
/ 2006 / The cutoff points of waist circumference for abdominal obesity / Korean Society for the Study of Obesity 15 : 1 ~ 9
Bennet AM / 2007 / Association of apolipoprotein E genotypes with lipid levels and coronary risk / JAMA 298 : 1300 ~ 1311
Chiba T / 2003 / VLDL induces adipocyte differentiation in ApoE-dependent manner / Arterioscler Thromb Vasc Biol 23 : 1423 ~ 1429
Elosua R / 2003 / Obesity modulates the association among APOE genotype, insulin, and glucose in men / Obes Res 11 : 1502 ~ 1508
/ 2006 / The cutoff points of waist circumference for abdominal obesity / Korean Society for the Study of Obesity 15 : 1 ~ 9
Bennet AM / 2007 / Association of apolipoprotein E genotypes with lipid levels and coronary risk / JAMA 298 : 1300 ~ 1311
Chiba T / 2003 / VLDL induces adipocyte differentiation in ApoE-dependent manner / Arterioscler Thromb Vasc Biol 23 : 1423 ~ 1429
Elosua R / 2003 / Obesity modulates the association among APOE genotype, insulin, and glucose in men / Obes Res 11 : 1502 ~ 1508
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