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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 123 - 129 (7page)
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초록· 키워드
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Purpose: This study was performed to estimate the
response rate and toxicity of a combination chemotherapy,
which included infusional 5-Fluorouracil, Leucovorin
and Docetaxel in the treatment of patients with an
advanced gastric carcinoma.
Materials and Methods: Twenty two advanced gastric
cancer patients, with a bidimensionally measurable or an
evaluable disease, were enrolled in this study. The patients
received a 5-fluorouracil 1,000 mg/m2 intravenous
(IV) 24 hour infusion (Day 1∼3), leucovorin 20 mg/m2
(Day 1∼3) and docetaxel 75 mg/m2 intravenously (Day
2) every 3 weeks.
Results: The overall response rate was 45.0%. The
median duration of response was 10.0 weeks (range: 4∼
24), the median time to response was 8 weeks (range:
8∼20) the median time to progression was 30.0 weeks
(95% CI: 16.3∼43.2) and the median overall survival
duration was 36.0 weeks (95% CI: 1.7∼70.2). The median
cumulative dose of 5-fluorouracil were 316.2 mg/m2/week
and docetaxel was 23.9 mg/m2/week. WHO grade III, IV
neutropenia, thromocytopenia and anemia occurred in
50.0%, 4.5% and 4.5% of patients, respectively. There were
no occurrence of WHO grade III and IV nausea, vomiting,
mucositis, conspitation, diarrhea, or neurotoxicity.
Conclusion: This chemotherapy regimen, including infusional
5-fluorouracil, leucovorin and docetaxel was an
active agent against advanced gastric cancer patients,
especially for previous chemotherapy naive patients.
(Cancer Res Treat. 2003;35:123-129)
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