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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 416 - 420 (5page)
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초록· 키워드
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Purpose: To evaluate the efficacy and safety of
ifosfamide, carboplatin and epirubicin (ICE) combination
chemotherapy for extensive disease small cell lung
cancer (SCLC) patients, who had received no previous
chemotherapy, we performed phase II trial between
August 1998 and January 2001.
Materials and Methods: The study group comprised of
21 patients. Ifosfamide, 1,500 mg/m2, was given with
mesna, 900 mg/m2, intravenously for 12 hours on days
1, 2 and 3, and carboplatin, 4.5 mg/ml/min, for target AUC,
and epirubicin, 60 mg/m2, were given intravenously for
90 minutes on day 1. The cycle of treatment was repeated
at 4 week intervals.
Results: Twenty-one patients with extensive disease
SCLC were treated at Hallym University between August
1998 and January 2001. One patient was unable to be
evaluated because of lost to follow-up. Of the 20 patients
able to be evaluated, an objective response was observed
in 13 (65%). There were no complete responses. The
median response duration, time to progression and
median overall survival were 15.4, 18.3 and 34 weeks,
respectively. Toxicities were acceptable, with dose reduction
for myelosuppression necessary in only a
minority of the patients. A total of 85 cycles of chemotherapy
were given to the patients. The median number
of cycles completed was 4. Grade III and IV hematological
toxicities included anemia (4.7%), neutropenia (3.5%) and
thrombocytopenia (3.5%). Most non-hematological toxicities
were grade I or II.
Conclusion: These results suggested that ICE combination
chemotherapy for extensive disease SCLC is
effective, and can be safely administered with acceptable
toxicities. (Cancer Res Treat. 2002;34:416-420
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