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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,452 - 1,457 (6page)
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초록· 키워드
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Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. The tumor is composed of predominantly lobulated cellular nodules separated by hyalinized fibrous stroma and they expressed CD10, -catenin (nuclear), and cyclin D1. Molecular analysis identified a point mutation (c.110C>G) in exon 3 of CTNNB1. The histopathological features, immunohistochemistry profiles, and molecular analysis of this tumor were consistent with MCST of the ovary. Therefore, a diagnosis of MCST of the right testicle was determined. To the best of our knowledge, this is the first case of MCST occurring in the testicles. The study may provide new insights to the tumor biology of MCST and a better understanding of this rare entity.
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참고문헌 (15)
참고문헌 신청
Irving JA / 2009 / Microcystic stromal tumor of the ovary: report of 16 cases of a hitherto uncharacterized distinctive ovarian neoplasm / Am J Surg Pathol 33:367~375
Irving JA / 2015 / Microcystic stromal tumor: a distinctive ovarian sex cordstromal neoplasm characterized by FOXL2, SF-1, WT-1, cyclin D1, and beta-catenin nuclear expression and CTNNB1 mutations / Am J Surg Pathol 39:1420~1426
Moch H / 2016 / The 2016 WHO classification of tumours of the urinary system and male genital organs: part A: renal, penile, and testicular tumours / Eur Urol 70:93~105
Young RH / 2005 / Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems / Mod Pathol 18(Suppl 2):S81~S98
Horta M / 2015 / Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists / Diagn Interv Radiol 21:277~286
Irving JA / 2015 / Microcystic stromal tumor: a distinctive ovarian sex cordstromal neoplasm characterized by FOXL2, SF-1, WT-1, cyclin D1, and beta-catenin nuclear expression and CTNNB1 mutations / Am J Surg Pathol 39:1420~1426
Moch H / 2016 / The 2016 WHO classification of tumours of the urinary system and male genital organs: part A: renal, penile, and testicular tumours / Eur Urol 70:93~105
Young RH / 2005 / Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems / Mod Pathol 18(Suppl 2):S81~S98
Horta M / 2015 / Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists / Diagn Interv Radiol 21:277~286
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