Histomorphology and Immunohistochemistry of Gastrointestinal Stromal Tumors in a Malaysian Population

Kkrishnappa, Purushotham; Loh, Eu Jhin; Mohamad, Ibtisam Binti; Tata, Mahadevan Deva; Akhilesh, Meenakshi; Palayan, Kandasami

추천

검색

자료유형: 학술저널

저자정보: Kkrishnappa, Purushotham (Pathology, Medicine, International Medical University) Loh, Eu Jhin (Pathology, Medicine, International Medical University) Mohamad, Ibtisam Binti (Department of Pathology, Hospital Tuanku Ja'afar) Tata, Mahadevan Deva (Department of Surgery, Hospital Tuanku Ja'afar) Akhilesh, Meenakshi (Pathology, Medicine, International Medical University) Palayan, Kandasami (Department of Surgery, Hospital Tuanku Ja'afar)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제6호

발행연도: 2016.1

수록면: 2,795 - 2,799 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: To study histomorphological and immunohistochemical patterns of gastro-intestinal stromal tumours (GISTs) in Malaysia. Materials and Methods: A total of 29 GIST cases from Hospital Tuanku Ja'afar, Seremban, were studied retrospectively over a period of 10 years from January 2002 to December 2011. Patient demographic data like age, sex and etnicity were collected. Tumour characteristics like site, maximum dimension and specimen type were analysed. Evaluation was according to established criteria into very low, low, intermediate and high-risk categories. Immunohistochemical characteristics were also analysed. Results: The mean age of patients was 59.7 years. Males (59%) were found to be more commonly affected than females (41%). The Chinese (45%) were commonly affected than Malays (41%), and Indians (10%). The most common symptom was pain in the abdomen (13.8%). More than half of the cases were seen in stomach (53%). The tumour size ranged from 1.5 cm to 17 cm with a mean of 6.94cm. Microscopic findings revealed that the spindle cell type was the most common (76%). It was observed that the majority of the cases (48%) were categorised in the intermediate risk group. Immunohistochemical staining showed positivity for CD117 (78.6%), CD34 (71.4%), vimentin (86.2%), S-100 (27.6%), SMA (35.7%), PKC THETA (46.4%) and PDGRFA (67.9%).

#Gastrointestinal stromal tumor #immunohistochemistry #risk categories #spindle cell #CD 117

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!