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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 157 - 162 (6page)
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Microcystic stromal tumor (MCST) of the ovary is a rare subtype of ovarian tumor first described in 2009. Although high nuclear expression of β-catenin and β-catenin gene (CTNNB1) mutation are related with ovarian MCST, the origin and genetic background of ovarian MCST remain unclear. In this study, two cases of ovarian MCST are presented. Microscopically, the tumors showed a microcystic pattern and regions with lobulated cellular masses with intervening hyalinized, fibrous stroma. Tumor cells of both cases were stained with CD10, vimentin, and Wilms tumor 1. Genetic analysis was performed and β-catenin gene (CTNNB1) mutation in exon 3 was detected in both cases. This is the first report in regards of detecting CTNNB1 mutation in ovarian MCST through the use of pyrosequencing (a novel sequencing technique).
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참고문헌 (10)
참고문헌 신청
Irving JA / 2009 / Microcystic stromal tumor of the ovary: report of 16 cases of a hitherto uncharacterized distinctive ovarian neoplasm / Am J Surg Pathol 33:367~375
Maeda D / 2011 / β-catenin(CTNNB1)S33C mutation in ovarian microcystic stromal tumors / Am J Surg Pathol 35:1429~1440
Yang M / 2014 / Ovarian microcystic stromal tumor : report of a new entity with immunohistochemical and ultrastructural studies / Ultrastruct Pathol 38:261~267
Kang YN / 2015 / Microcystic stromal tumor of the ovary with mutation in exon 3 of β-catenin: a case report / Int J Gynecol Pathol 34:121~125
Lee SH / 2015 / Ovarian microcystic stromal tumor: a novel extracolonic tumor in familial adenomatous polyposis / Genes Chromosomes Cancer 54:353~360
Maeda D / 2011 / β-catenin(CTNNB1)S33C mutation in ovarian microcystic stromal tumors / Am J Surg Pathol 35:1429~1440
Yang M / 2014 / Ovarian microcystic stromal tumor : report of a new entity with immunohistochemical and ultrastructural studies / Ultrastruct Pathol 38:261~267
Kang YN / 2015 / Microcystic stromal tumor of the ovary with mutation in exon 3 of β-catenin: a case report / Int J Gynecol Pathol 34:121~125
Lee SH / 2015 / Ovarian microcystic stromal tumor: a novel extracolonic tumor in familial adenomatous polyposis / Genes Chromosomes Cancer 54:353~360
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