지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 263 - 273 (11page)
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Purpose This study evaluated the benefits of adjuvant chemotherapy on elderly patients with advanced gastric cancer (AGC) using meta-analysis of well-designed randomized controlled clinical studies.
Materials and Methods PubMed, Embase, and Cochrane were searched to retrieve clinical studies evaluating the benefits of adjuvant chemotherapy in the elderly with AGC. Hazards ratios (HRs) with 95% confidence intervals (CIs) were pooled across studies using a fixed-effects model.
Results Two studies were included in this meta-analysis to estimate HR for the overall survival (OS), and relapse-free survival (RFS) between adjuvant chemotherapy and surgery in elderly and non-elderly patients. HR for OS in the elderly and non-elderly was 0.745 (95% CI, 0.552 to 1.006, p=0.055) and 0.636 (95% CI, 0.522 to 0.776; p < 0.001), respectively, which showed no heterogeneity regarding HR between the two groups (pinteraction=0.389). HR for RFS in the elderly and non-elderly was 0.613 (95% CI, 0.466 to 0.806; p < 0.001) and 0.633 (95% CI, 0.533 to 0.753; p < 0.001), respectively (pinteraction=0.846).
Conclusion Meta-analysis suggests that the benefit of adjuvant chemotherapy to the elderly is not big enough to reach statistical significance while the HR for OS is less than 1 (0.745) and no heterogeneity are observed regarding the HR between the elderly and non-elderly patients.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Arai T / 2004 / Pathologic characteristics of gastric cancer in the elderly : a retrospective study of 994 surgical patients / Gastric Cancer 7 : 154 ~ 159
Bang YJ / 2012 / Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy(CLASSIC) : a phase 3 open-label, randomised controlled trial / Lancet 379 : 315
Bouche O / 2005 / Adjuvant chemotherapy with 5-fluorouracil and cisplatin compared with surgery alone for gastric cancer : 7-year results of the FFCD randomized phase III tri
Cancer Genome Atlas Research Network / 2014 / Comprehensive molecular characterization of gastric adenocarcinoma
Cascinu S / 2007 / Adjuvant treatment of high-risk, radically resected gastric cancer patients with 5-fluorouracil, leucovorin, cisplatin, and epidoxorubicin in a randomized
Bang YJ / 2012 / Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy(CLASSIC) : a phase 3 open-label, randomised controlled trial / Lancet 379 : 315
Bouche O / 2005 / Adjuvant chemotherapy with 5-fluorouracil and cisplatin compared with surgery alone for gastric cancer : 7-year results of the FFCD randomized phase III tri
Cancer Genome Atlas Research Network / 2014 / Comprehensive molecular characterization of gastric adenocarcinoma
Cascinu S / 2007 / Adjuvant treatment of high-risk, radically resected gastric cancer patients with 5-fluorouracil, leucovorin, cisplatin, and epidoxorubicin in a randomized
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