The Association Between Circulating  Inflammatory Markers and Metabolic Syndrome  in Korean Rural Adults

류소연; Ryu; 김기순; 박종; 강명근; 한미아

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자료유형: 학술저널

저자정보: 류소연 Ryu 김기순 박종 강명근 한미아

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제41권 제6호

발행연도: 2008.1

수록면: 413 - 418 (6page)

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연구주제

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연구배경

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연구방법

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Objectives : This study was performed to investigate the associations between the metabolic syndrome (MetS) and inflammatory markers. Methods : This cross-sectional analysis was performed using data from 1578 Koreans aged 40-69 years residing in a rural area. We investigated associations between MetS and circulating high sensitivity C-reactive protein (hs-CRP), white blood cells (WBC) and adiponectin. MetS was defined using the criteria proposed by the National Cholesterol Education Program Adult Treatment Panel III (ATP-III). Results : Increased WBC counts and hs-CRP levels and decreased adiponectin levels were observed in subjects with MetS. WBC, hs-CRP and adiponectin levels linearly deteriorated with an increase in the number of MetS components (all ptrend <0.005). Finally, adjusted odds ratios (ORs) for the risk of MetS by increase/decrease in 3 inflammatory markers were calculated by multivariate logistic regression analyses. In terms of changes in inflammation markers, in men, the adjusted ORs (95% confidence interval) were 1.15 (1.01-1.31) for WBC, 1.64 (1.02-2.64) for hs-CRP, and 0.19 (0.08-0.45) for adiponectin, whereas corresponding adjusted ORs (95% CIs) in women were 1.27 (1.15-1.40), 0.98 (0.67-1.42), 0.09 (0.04-0.18), respectively. Conclusions : Serum adiponectin levels and WBC counts were found to be strongly associated with MetS in both sexes. However, hs-CRP lost its significance after adjusting for BMI and other inflammatory markers in women. This study shows that inflammatory response is associated with MetS in the Korean population. Further prospective studies are necessary to confirm the contribution made by inflammatory markers to the development of MetS.

#Adiponectin #C-reactive protein #Inflammation #Metabolic syndrome #White blood cells

참고문헌 (22)

참고문헌 신청

Choi KM / 2004 / Serum adiponectin concentrations predict the development of type 2 diabetes and the metabolic syndrome in elderly Koreans / Clin Endocrinol 61 (1) : 75 ~ 80

Choi KM / 2007 / Serum adiponectin, interleukin- 10 levels and inflammatory markers in the metabolic syndrome / Diabetes Res Clin Pract 75 (2) : 235 ~ 240

Desai MY / 2006 / Association of body mass index, metabolic syndrome, and leukocyte count / Am J Cardiol 79 (6) : 835 ~ 838

Festa A / 2000 / Chronic subclinical inflammation as part of the insulin resistance syndrome:

Ford ES / 2002 / Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey / JAMA 287 (3) : 356 ~ 359

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