연구목적: 폐경 및 폐경주변기 여성에서 혈청 ferritin과 대사증후군에 대하여 알아보았다.
연구재료 및 방법: 2007년 1월부터 4월까지 종합병원 건강증진센터를 방문한 2,091명을 대상으로 대사증후군 (metabolic syndrome, MetS)과 대사증후군이 아닌 군 (non-metabolic syndrome group, Non-MetS) 간 비교하였다.
결과: 평균 혈청 ferritin 수치는 MetS 65.16 ± 33.69 ng/mL, Non-MetS 57.82 ± 32.51 ng/mL이었다 (P = 0.000). MetS에서 혈청 ferritin과의 상관관계는 헤모글로빈, 인슐린, homeostasis model assessment of insulin resistance (HOMA-IR), 중성지방, aspartate transaminase (SGOT), alanine transaminase (SGPT), 혈청 요산, high-sensitivity C-reactive protein (hs-CRP)와 약한 양의 상관관계를 보였고 고밀도 지단백, 저밀도 지단백과는 약한 음의 상관관계를 보였으며 (P < 0.05) 다단계 다중회귀분석상 hs-CRP, 고밀도 지단백, SGOT, HOMA-IR, 헤모글로빈 수치가 유의하였다 (R2 = 0.106; P < 0.05).
결론: 혈청 ferritin 수치가 MetS에서 Non-MetS보다 유의하게 높았고, hs-CRP, SGOT, HOMA-IR, 헤모글로빈 수치가 증가할수록 고밀도 지단백 수치는 낮아질수록 증가하였다.
Objectives: The purpose of this study was to examine the relationship between serum ferritin and metabolic syndrome in peri- and postmenopausal women.
Methods: The study subjects consisted of 2,091 peri- and postmenopausal women who visited the hospital for a health check-up in 2007. They were divided into the metabolic syndrome group (MetS) and the non-metabolic syndrome group (Non-MetS).
Results: Mean serum ferritin values were 65.16 ± 33.69 ng/mL in MetS and 57.82 ± 32.51 ng/mL in Non-MetS (P = 0.000). In MetS, serum ferritin had a positive correlation with hemoglobin (Hb), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, aspartate transaminase (SGOT), alanine transaminase (SGPT), uric acid, and high-sensitivity C-reactive protein (hs-CRP) but a negative correlation with high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol (P < 0.05). From multiple linear models, hs-CRP, HDL-cholesterol, SGOT, HOMA-IR, and hemoglobin level were found to be the best predictors of serum ferritin in MetS (R2 = 0.106; P < 0.05).
Conclusion: The serum ferritin level in MetS was higher than in Non-MetS in postmenopausal women. In MetS, with increasing hs-CRP, SGOT, HOMA-IR, and hemoglobin levels and decreasing HDL-cholesterol levels, the serum ferritin level seems to increase. (J Korean Soc Menopause 2011;17:166-173)