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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 170 - 174 (5page)
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초록· 키워드
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Purpose: CD44 is a multifunctional adhesion molecule
in cell-to-cell and cell-to-matrix interactions. This transmembrane
glycoprotein exists in either standard or variant
form, with the variation originating in alternative
splicing. This study was designed to evaluate the role of
CD44v6, one of the CD44 isoforms, in hepatocellular carcinoma
and cholangiocarcinoma.
Materials and Methods: Immunohistochemical expression
of CD44v6 was studied in 7 normal livers, 14 hepatocellular
carcinomas and 16 cholangiocarcinomas, that
were formalin fixed and paraffin embedded.
Results: CD44v6 was frequently expressed in the normal
hepatocytes and hepatocellular carcinomas. Expression
was not noted in the normal bile duct within the portal
tract. CD44v6 was positively expressed in some of the
proliferating bile ducts (43%) and cholangiocarcinomas
(69%).
Conclusion: CD44v6 expression may be more important
in the stepwise carcinogenesis of the bile duct than in the
normal hepatocyte, but further study is needed.
(Cancer Res Treat. 2002;34:170-174)
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