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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 117 - 121 (5page)
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초록· 키워드
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Purpose: β-catenin is an intracellular protein that is an
integral component of the cadherin-mediated cell-cell
interaction and a downstream transcriptional activator in
the wnt signal transduction pathway. Inappropriate activation
of β-catenin has recently been implicated in the
development of hepatocellular carcinoma and cholangiocarcinoma.
Nuclear β-catenin expression is strongly
associated with gene mutation. This study was designed
to evaluate the pattern of β-catenin expression between
hepatocellular carcinoma and cholangiocarcinoma.
Materials and Methods: Immunohistochemical expression
of β-catenin was studied in 7 normal livers, 33
hepatocellular carcinomas and 20 cholangiocarcinomas,
that were formalin fixed and paraffin embedded.
Results: β-catenin was expressed mainly in the cytoplasmic
membrane of the normal hepatocytes and bile
ducts. Nuclear expressions, not noted in the normal liver,
were noted in 30% of the hepatocellular carcinomas and
10% of the cholangiocarcinomas. And, nuclear expression
was more common in the high grade (50%) hepatocellular
carcinomas than the low grade (18%) hepatocellular
carcinomas (p≤0.05).
Conclusion: The above results indicate that nuclear
expression of β-catenin is observed in the carcinoma but
not the normal liver, and is associated with high grade
liver carcinoma. (Cancer Res Treat. 2002;34:117-121)
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