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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 125 - 132 (8page)
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초록· 키워드
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Purpose The aim of study was to test by immunohistochemical (IHC) staining whether carbonic anhydrase (CA) 9 and 12 have an effect on sentinel lymph node (SLN) metastasis in early breast cancer and to find clinicopathologic factors associated with SLN metastasis.
Materials and Methods Between June 2003 and June 2011, medical records of 470 patients diagnosed with breast cancer with pT1-2, pN0-2, and M0 were reviewed. Of these 470, 314 patients who under- went SLN biopsy±axillary dissection were subjects of this study. Using tissue microarray, IHC staining for CA9 and CA12 was performed. Clinicopathologic factors such as patient age, tumour size, lymphatic invasion, hormone receptor status, and the Ki-67 labeling index were analysed together.
Results The mean age of all patients was 51.7 years. The mean number of harvested SLN was 3.62, and 212 patients (67.5%) had negative SLN. Lymphatic invasion, the Ki-67 labelling index of primary tumours, and CA9 staining of stromal cells, were independent risk factors for SLN metastasis in the multivariate analysis. In 33 patients (10.5%) without the three risk factors, no patient had SLN metastasis. In 80 patients without lymphatic invasion of primary tumours or CA9 staining of stromal cells, only four patients (5%) had positive SLN.
Conclusion CA9 staining of stromal cells is an independent risk factor for SLN metastasis as well as lymphatic invasion and a low Ki-67 labelling index of primary tumours in patients with early breast cancer. IHC staining of primary tumours for CA12 was not associated with SLN metas- tasis.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Sugie T / 2013 / Comparison of the indocyanine green fluorescence and blue dye methods in detection of sentinel lymph nodes in early-stage breast cancer / Ann Surg Oncol 20:2213~2218
Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347:1227~1232
Ugras S / 2014 / Estrogen receptor, progesterone receptor, and HER2 status predict lymphovascular invasion and lymph node involvement / Ann Surg Oncol 21:3780~3786
이종훈 / 2010 / Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size / Cancer Research and Treatment 42(1):30~36
Brahimi-Horn MC / 2007 / Hypoxia and cancer / J Mol Med(Berl) 85:1301~1307
Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347:1227~1232
Ugras S / 2014 / Estrogen receptor, progesterone receptor, and HER2 status predict lymphovascular invasion and lymph node involvement / Ann Surg Oncol 21:3780~3786
이종훈 / 2010 / Predictors of Axillary Lymph Node Metastases (ALNM) in a Korean Population with T1-2 Breast Carcinoma: Triple Negative Breast Cancer has a High Incidence of ALNM Irrespective of the Tumor Size / Cancer Research and Treatment 42(1):30~36
Brahimi-Horn MC / 2007 / Hypoxia and cancer / J Mol Med(Berl) 85:1301~1307
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