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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 30 - 36 (7page)
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Purpose :We estimated the likelihood of breast cancer patients having axillary lymph node metastases (ALNM) based on a variety of clinical and pathologic factors.
Materials and Methods :Three hundred sixty-one breast cancer patients without distant metastases and who underwent breast conserving surgery and axillary lymph node dissection (ALND) (level I and II) or modified radical mastectomy (MRM) were identified, and we retrospectively reviewed their pathology records and treatment charts.
Results :Positive axillary lymph nodes were detected in 104 patients for an overall incidence of 28.8%: 2 patients (5%) with T1a tumor, 5 (9.2%) with T1b tumor, 24 (21.8%) with T1c tumor and 73 (44.2%) with T2 tumor. On the multivariate analysis, an increased tumor size (adjusted OR=11.87, p=0.02), the presence of lymphovascular invasion (adjusted OR=7.41, p＜0.01), a triple negative profile (ER/PR-, Her2-) (adjusted OR=2.09, p=0.04) and a palpable mass at the time of diagnosis (adjusted OR=2.31, p=0.03) were all significant independent factors for positive ALNM.
Conclusion :In our study, the tumor size, the presence of lymphovascular invasion, a triple negative profile and a palpable mass were the independent predictive factors for ALNM. The tumor size was the strongest predictor of ALNM. Thus, the exact estimation of the extent of tumor is necessary for clinicians to optimize the patients’ care. Patients with a triple negative profile have a high incidence of ALNM irrespective of the tumor size.
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참고문헌 (25)
참고문헌 신청
[학술지(정기간행
/ 1991 / NIH Consensus Conference, Treatment of early-stage breast cancer / JAMA 265 : 391 ~ 395
Bader AA / 2002 / T1 breast cancer: identification of patients at low risk of axillary lymph node metastases / Breast Cancer Res Treat 76 : 11 ~ 17
Bevilacqua J / 2002 / A prospective validated model for predicting axillary node metastases based on 2000 sentinel node procedures: the role of tumor location [corrected] /
Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295 : 2492 ~ 2502
/ 1991 / NIH Consensus Conference, Treatment of early-stage breast cancer / JAMA 265 : 391 ~ 395
Bader AA / 2002 / T1 breast cancer: identification of patients at low risk of axillary lymph node metastases / Breast Cancer Res Treat 76 : 11 ~ 17
Bevilacqua J / 2002 / A prospective validated model for predicting axillary node metastases based on 2000 sentinel node procedures: the role of tumor location [corrected] /
Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295 : 2492 ~ 2502
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