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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 87 - 92 (6page)
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초록· 키워드
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Purpose :
HuR, human family embryonic-lethal abnormal vision-like protein, can bind to mRNA and stabilizes the nucleic acid in the cytoplasm, resulting in more efficient translation. HuR is predominantly present in the nucleus and shuttles between the nucleus and cytoplasm. HuR stabilizes cyclooxygenase-2 (Cox-2) mRNA in several cancers, including breast, stomach, lung and brain cancer.
Materials and Methods :
We investigated the expression and cellular location of HuR, as well as evaluated Cox-2 expression in 79 colorectal cancer patients with the use of immunohistochemical methods. The biological implications of HuR localization and Cox-2 expression in colorectal carcinoma were evaluated.
Results :
Nuclear HuR expression was observed in 59 (74.7%) tumors and cytoplasmic HuR expression was seen in 25 (31.6%) tumors. Cox-2 immunoreactivity was noted in 42 (53%) tumors. The expression of cytoplasmic HuR was significantly associated with Cox-2 expression (p=0.004). Cytoplasmic expression of HuR showed a correlation with lymphatic invasion (p=0.025) and the presence of a lymph node metastasis (p=0.027). The presence of
nuclear HuR showed no correlation with Cox-2 expression or any other of the
clinicopathological parameters that were examined.
Conclusion :
These results suggest that cytoplasmic translocation of HuR is associated with Cox-2 expression for some colorectal carcinomas.
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참고문헌 (25)
참고문헌 신청
/ / Korea National Statistical Office. Death by cause. Korean Stational Information Service (KOSIS).
Atasoy U / 1998 / ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation / J Cell Sci 111 :
Chen CY / 1995 / AU-rich elements: characterization and importance in mRNA degradation / Trends Biochem Sci 20 : 465 ~ 470
Denkert C / 2004 / Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclo
Dixon DA / 2000 / Posttranscriptional control of cyclooxygenase-2 gene expression. The role of the 3'-untranslated region / J Biol Chem 275 : 11750 ~ 11757
Atasoy U / 1998 / ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation / J Cell Sci 111 :
Chen CY / 1995 / AU-rich elements: characterization and importance in mRNA degradation / Trends Biochem Sci 20 : 465 ~ 470
Denkert C / 2004 / Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclo
Dixon DA / 2000 / Posttranscriptional control of cyclooxygenase-2 gene expression. The role of the 3'-untranslated region / J Biol Chem 275 : 11750 ~ 11757
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Correlation Between Cyclooxygenase-2 Expression and HuR Cytoplasmic Translocation of Breast Cancer
Journal of Pathology and Translational Medicine
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Expression of Cyclooxygenase-2 and Embryonic Lethal Abnormal Vision- Like Protein HuR in Gallbladder Carcinoma
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Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis
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Cyclooxygenase-2 and p53 Expression as Prognostic Indicators in Conventional Renal Cell Carcinoma
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