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학술저널
저자정보
Mahmoud, Abla Sayed (Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry) Umair, Ayesha (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry) Azzeghaiby, Saleh Nasser (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry) Alqahtani, Fahad Hussain (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry) Hanouneh, Salah (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry) Tarakji, Bassel (Department of Oral Maxillofacial Sciences, Alfarabi College of Nursing and Dentistry)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제16호
발행연도
2014.1
수록면
6,787 - 6,790 (4page)

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Background: The aim of this study was to evaluate cyclooxygenase-2 (COX-2) immunoreactivity in colorectal adenocarcinomas and to find correlations with different pathological features. Materials and Methods: This study included 35 cases of colorectal carcinoma foir which surgical colectomy specimens were collected. Immunohistochemical staining of COX-2 (cyclooxygenase-2) is done by using the Streptavidin-biotin technique. Results: This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features. Conclusions: Our data suggest over expression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis.

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