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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 145 - 154 (10page)
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Purpose :
To evaluate the effect of X-ray irradiation on apoptosis and change of expression of aquaporin 5 (AQP5) and transforming growth factor-β(TGF-β) in the rat submandibular gland (SMG).
Materials and Methods :
SMGs of 120 male Sprague-Dawley rats were irradiated with a single X-ray dose (3, 10, 20, or 30 Gy). At the early and late post-irradiation phase, apoptosis was measured by the terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL) method, and expression of AQP5 and TGF-βwas determined by immunohistochemical staining.
Results :
At the late post-irradiation phase, increased apoptosis was evident and marked decreases of expression of AQP5 expression by acinar cells and TGF-βexpression by ductal cells were evident.
Conclusion :
Apoptosis after X-ray irradiation develops relatively late in rat SMG. Irradiation reduces AQP5 and TGF-βexpression in different SMG cell types.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Abok K / 1984 / Morphologic and histochemical studies on the differing radiosensitivity of ductular and acinar cells of the rat submandibular gland / Virchows Arch B Cell Pat
Anscher MS / 1994 / Changes in plasma TGF beta levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis / Int J Radiat Oncol Biol
Coppes RP / 2001 / Early to late sparing of radiation damage to the parotid gland by adrenergic and muscarinic receptor agonists / Br J Cancer 85 : 1055 ~ 1063
Dorr W / 2001 / Consequential late effects in normal tissues / Radiother Oncol 61 : 223 ~ 231
Feltl D / 2005 / Post-treatment plasma transforming growth factor beta 1 (TGF-beta1) level predicts for late morbidity in patients with advanced head and neck cancer / Neopl
Anscher MS / 1994 / Changes in plasma TGF beta levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis / Int J Radiat Oncol Biol
Coppes RP / 2001 / Early to late sparing of radiation damage to the parotid gland by adrenergic and muscarinic receptor agonists / Br J Cancer 85 : 1055 ~ 1063
Dorr W / 2001 / Consequential late effects in normal tissues / Radiother Oncol 61 : 223 ~ 231
Feltl D / 2005 / Post-treatment plasma transforming growth factor beta 1 (TGF-beta1) level predicts for late morbidity in patients with advanced head and neck cancer / Neopl
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