RB1 Polymorphism Contributes to the Efficacy of Platinum-Taxanes in Advanced Squamous Cell Lung Cancer

Liu, Di; Xu, Wen; Zhang, Zhi-Wei; Qian, Ji; Zheng, Hui; Zhang, Jie; Su, Bo

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자료유형: 학술저널

저자정보: Liu, Di (Central Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine) Xu, Wen (Central Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine) Zhang, Zhi-Wei (Central Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine) Qian, Ji (Fudan University Shanghai Cancer Center, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University) Zheng, Hui (Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine) Zhang, Jie (Department of oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine) Su, Bo (Central Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제2호

발행연도: 2015.1

수록면: 775 - 781 (7page)

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Background: RB1 (retinoblastoma 1) was reportedly one of the major determinative factors for sensitivity to taxanes in previous studies. In this study, we investigated the influence of RB1 single nucleotide polymorphisms (SNPs) on the efficacy of platinum-taxane regimens in advanced NSCLC patients. Materials and Methods: 234 cases of patients with advanced NSCLC who were treated with first-line platinum-taxane agents were enrolled in this study. Genomic DNA was extracted from patients' peripheral blood samples using a QIAamp DNA Maxi Kit, and genotyped by iSelect HD Bead-Chip. Results: Regression analyses were conducted through the univariate and multivariate Cox proportional hazards model in the 234 patients. The results showed that of the eight RB1 tagSNPs, only rs4151510 was a positive predictive factor for the advanced NSCLC patients treated with platinum taxanes regimen. The patients with G/G genotype of RB rs4151510 had longer overall survival (OS) than the non-G/G genotype (p=0.018). The histology was also correlated with OS in the whole advanced NSCLC patients. Three tagSNPs of RB1, rs4151510, rs4151465, rs9568036 were significantly associated with OS in the advanced NSCLC patients with squamous cell histology using Kaplan-Meier overall survival analysis stratified by histology. Conclusions: RB1 genomic variants were correlated with the efficacy of platinum-taxanes regimen. RB rs4151510 is an independent factor of the prognosis of NSCLC patients receiving platinum-taxane chemotherapy.

#Chemotherapy #RB1 #single nucleotide polymorphism #lung cancer

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